FOSL1
Fos-related antigen 1
Protein Summary
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
- ENST00000312562
- ENSP00000310170
- ENSG00000175592
- ENST00000448083
- ENSP00000393302
- FRA1
- FRA
- FRA1
- fra-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
gene perturbation | 1 | ||
biological process | 0.95 | ||
small molecule perturbation | 0.93 | ||
chemical | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 381.11 (req: < 5)
Gene RIFs: 131 (req: <= 3)
Antibodies: 373 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 381.11 (req: >= 5)
Gene RIFs: 131 (req: > 3)
Antibodies: 373 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 29
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0