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Tchem
FOLR2
Folate receptor beta

Protein Summary
Description
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rhe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298223
  • ENSP00000298223
  • ENSG00000165457

Symbol
  • FBP
  • FR-P3
  • FR-BETA
  • BETA-HFR
  • FBP/PL-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
tissue sample
0.67
cell line
0.64
molecular function
0.63
cellular component
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.21   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.21   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 36
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3