Tclin FOLR1 Folate receptor alpha

Protein Summary

Description

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• P15328
• Q53EW2
• Q6FGT8
• Q6LC90
• Q9UCT2
• FR-alpha

Gene Name

• FOLR1

Ensembl ID

• ENST00000312293
• ENSP00000308137
• ENSG00000110195
• ENST00000393676
• ENSP00000377281
• ENST00000393679
• ENSP00000377284
• ENST00000393681
• ENSP00000377286

Symbol

• FOLR
• FBP
• FOLR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.82
transcription factor perturbation	0.8
disease perturbation	0.79
gene perturbation	0.77
small molecule perturbation	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 416.76   (req: < 5)

Gene RIFs: 117   (req: <= 3)

Antibodies: 432   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 416.76   (req: >= 5)

Gene RIFs: 117   (req: > 3)

Antibodies: 432   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 56

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5