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Tclin
FOLH1
Glutamate carboxypeptidase 2

Protein Summary
Description
Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and cons ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256999
  • ENSP00000256999
  • ENSG00000086205
  • ENST00000340334
  • ENSP00000344131
  • ENST00000356696
  • ENSP00000349129
  • ENST00000533034
  • ENSP00000431463

Symbol
  • FOLH
  • NAALAD1
  • PSM
  • PSMA
  • PSM
  • FGCP
  • FOLH
  • GCP2
  • PSMA
  • mGCP
  • GCPII
  • NAALAD1
  • NAALAdase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.83
cellular component
0.69
tissue
0.68
kinase perturbation
0.66
disease
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5660.66   (req: < 5)
Gene RIFs: 120   (req: <= 3)
Antibodies: 1127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5660.66   (req: >= 5)
Gene RIFs: 120   (req: > 3)
Antibodies: 1127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 240
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1