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Tbio
FNDC5
Fibronectin type III domain-containing protein 5

Protein Summary
Description
Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue. This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000496770
  • ENSP00000476320
  • ENSG00000160097
  • ENST00000640867
  • ENSP00000491708

Symbol
  • FRCP2
  • FRCP2
  • irisin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.76
gene perturbation
0.65
transcription factor perturbation
0.61
biological term
0.6
cellular component
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 964.15   (req: < 5)
Gene RIFs: 171   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 964.15   (req: >= 5)
Gene RIFs: 171   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
CAPN15
Tbio
Novelty:  0.01046841
p_int:  0.998804046
p_ni:  0.001195954
Score:  0.187
Data Source:  BioPlex,STRINGDB
TMCO3
Tdark
Novelty:  1.16719823
p_int:  0.998775491
p_ni:  0.000442732
p_wrong:  0.000781777
Data Source:  BioPlex
SLC9A1
Tchem
Family:  Transporter
Novelty:  0.00096678
p_int:  0.997422145
p_ni:  0.00257783
p_wrong:  2.5e-8
Score:  0.167
Data Source:  BioPlex,STRINGDB
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.996729656
p_ni:  0.003270344
Data Source:  BioPlex
ENDOD1
Tdark
Family:  Enzyme
Novelty:  0.26430864
p_int:  0.968644454
p_ni:  0.027724509
p_wrong:  0.003631037
Score:  0.189
Data Source:  BioPlex,STRINGDB
GNAL
Tbio
Novelty:  0.01757098
p_int:  0.961046272
p_ni:  0.009009477
p_wrong:  0.029944252
Score:  0.206
Data Source:  BioPlex,STRINGDB
RHBDD3
Tbio
Novelty:  0.04564748
p_int:  0.946152517
p_ni:  0.053327949
p_wrong:  0.000519534
Score:  0.189
Data Source:  BioPlex,STRINGDB
GHITM
Tbio
Novelty:  0.00360652
p_int:  0.871319763
p_ni:  0.128680237
Data Source:  BioPlex
UCP1
Tbio
Novelty:  0.00055954
Score:  0.916
Data Source:  STRINGDB
MSTN
Tclin
Novelty:  0.00062316
Score:  0.833
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
60.2
body mass index
1
1
1
59
visceral adipose tissue measurement
1
1
1
33.1
daytime rest measurement
1
1
1
15.7
mosaic loss of chromosome Y measurement
1
1
1
3.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
60.2
body mass index
1
59
visceral adipose tissue measurement
1
33.1
daytime rest measurement
1
15.7
mosaic loss of chromosome Y measurement
1
3.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibronectin type III domain containing 5
VGNC:10645
746970
Mouse
MGI:1917614
384061
Rat
RGD:708525
260327
Dog
fibronectin type III domain containing 5
VGNC:40931
487302
Horse
fibronectin type III domain containing 5
VGNC:50695
100146454
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibronectin type III domain containing 5
Mouse
Rat
Dog
fibronectin type III domain containing 5
Horse
fibronectin type III domain containing 5
Publication Statistics
PubMed Score 964.15
PubMed score by year
PubTator Score 412.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title