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Tbio
FNDC4
Fibronectin type III domain-containing protein 4

Protein Summary
Description
Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro-inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264703
  • ENSP00000264703
  • ENSG00000115226

Symbol
  • FRCP1
  • FRCP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
kinase perturbation
0.76
disease
0.72
cell type or tissue
0.71
tissue sample
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.23   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.23   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
TRPM4
Tchem
Family:  IC
Novelty:  0.00423106
p_int:  0.999869528
p_ni:  0.000129503
p_wrong:  9.69e-7
Score:  0.223
Data Source:  BioPlex,STRINGDB
GHITM
Tbio
Novelty:  0.00360652
p_int:  0.999274703
p_ni:  0.000725297
Data Source:  BioPlex
MT-ND5
Tclin
Family:  Enzyme
Novelty:  0.00223164
p_int:  0.997595744
p_ni:  0.002404174
p_wrong:  8.2e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
SLC9A6
Tbio
Family:  Transporter
Novelty:  0.01410234
p_int:  0.99665073
p_ni:  0.003110929
p_wrong:  0.00023834
Score:  0.19
Data Source:  BioPlex,STRINGDB
CAV1
Tbio
Novelty:  0.00035244
p_int:  0.990414635
p_ni:  0.00931189
p_wrong:  0.000273475
Score:  0.166
Data Source:  BioPlex,STRINGDB
MPRIP
Tbio
Family:  Enzyme
Novelty:  0.03253403
p_int:  0.986898979
p_ni:  0.013101021
Score:  0.181
Data Source:  BioPlex,STRINGDB
GALNT11
Tbio
Family:  Enzyme
Novelty:  0.09714947
p_int:  0.980821921
p_ni:  0.019178079
Score:  0.186
Data Source:  BioPlex,STRINGDB
MT-ND2
Tclin
Family:  Enzyme
Novelty:  0.00069255
p_int:  0.97354103
p_ni:  0.020669166
p_wrong:  0.005789804
Score:  0.219
Data Source:  BioPlex,STRINGDB
INTS7
Tdark
Novelty:  0.04592325
p_int:  0.967183123
p_ni:  0.032812671
p_wrong:  0.000004205
Data Source:  BioPlex
PPP1R10
Tbio
Family:  Enzyme
Novelty:  0.01119155
p_int:  0.947344107
p_ni:  0.052655294
p_wrong:  5.99e-7
Score:  0.19
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (181)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
71
19
93
7.7
100
C-reactive protein measurement
12
5
16
99.7
total cholesterol measurement
29
9
33
3.5
99.6
low density lipoprotein cholesterol measurement
48
5
49
99.3
high density lipoprotein cholesterol measurement
51
4
51
99.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
93
7.7
100
C-reactive protein measurement
16
99.7
total cholesterol measurement
33
3.5
99.6
low density lipoprotein cholesterol measurement
49
99.3
high density lipoprotein cholesterol measurement
51
99.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibronectin type III domain containing 4
VGNC:254
459106
Macaque
fibronectin type III domain containing 4
702098
Mouse
MGI:1917195
64339
Dog
fibronectin type III domain containing 4
VGNC:40930
483014
Cow
fibronectin type III domain containing 4
VGNC:29064
781806
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibronectin type III domain containing 4
Macaque
fibronectin type III domain containing 4
Mouse
Dog
fibronectin type III domain containing 4
Cow
fibronectin type III domain containing 4
Publication Statistics
PubMed Score 7.23
PubMed score by year
PubTator Score 1.27
PubTator score by year
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Related Publications
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PMID
Year
Title