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Tdark
FNBP4
Formin-binding protein 4

Protein Summary
Description
This gene encodes a protein containing two tryptophan-rich WW domains that binds the proline-rich formin homology 1 domains of formin family proteins, suggesting a role in the regulation of cytoskeletal dynamics during cell division and migration. It also binds intersectin family proteins suggesting a role in the maintenance of membrane curvature at sites of nascent vesicle formation. Naturally occurring mutations in this gene are associated with Waardenburg anophthalmia syndrome. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263773
  • ENSP00000263773
  • ENSG00000109920
  • ENST00000646180
  • ENSP00000494562
  • ENSG00000285182

Symbol
  • FBP30
  • KIAA1014
  • FBP30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.98
drug perturbation
0.96
transcription factor binding site profile
0.93
ligand (protein) perturbation
0.83
disease perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.66   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.66   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
DDX17
Tbio
Family:  Enzyme
Novelty:  0.00462781
p_int:  0.999999938
p_ni:  6.2e-8
Score:  0.445
Data Source:  BioPlex,STRINGDB
ZC3H18
Tdark
Novelty:  0.3515546
p_int:  0.999999367
p_ni:  6.33e-7
p_wrong:  1e-9
Score:  0.403
Data Source:  BioPlex,STRINGDB
DGKZ
Tchem
Family:  Enzyme
Novelty:  0.01312044
p_int:  0.999998823
p_ni:  0.000001176
p_wrong:  1e-9
Data Source:  BioPlex
FGF12
Tbio
Novelty:  0.02094849
p_int:  0.999996759
p_ni:  0.000003241
Data Source:  BioPlex
TRAP1
Tchem
Novelty:  0.03344189
p_int:  0.97990539
p_ni:  0.015436623
p_wrong:  0.004657986
Data Source:  BioPlex
ARHGAP12
Tbio
Family:  Enzyme
Novelty:  0.12113722
p_int:  0.931573455
p_ni:  0.00084479
p_wrong:  0.067581755
Data Source:  BioPlex
PNISR
Tdark
Novelty:  0.06559175
Score:  0.841
Data Source:  STRINGDB
SRSF11
Tbio
Novelty:  0.17035604
Score:  0.788
Data Source:  STRINGDB
FNBP1
Tbio
Novelty:  0.03879767
Score:  0.676
Data Source:  STRINGDB
WBP4
Tbio
Novelty:  0.10095907
Score:  0.654
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
12
5
19
95.1
neuroticism measurement
5
4
3
6.5
78.5
self reported educational attainment
2
2
2
73.4
neutrophil count
1
1
1
72.9
nervousness
1
2
0
8.1
69.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
19
95.1
neuroticism measurement
3
6.5
78.5
self reported educational attainment
2
73.4
neutrophil count
1
72.9
nervousness
0
8.1
69.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
formin binding protein 4
VGNC:1057
451177
Mouse
MGI:1860513
55935
Rat
RGD:1309238
311183
Dog
formin binding protein 4
VGNC:40926
483619
Horse
formin binding protein 4
VGNC:18085
100058440
Species
Name
OMA
EggNOG
Inparanoid
Chimp
formin binding protein 4
Mouse
Rat
Dog
formin binding protein 4
Horse
formin binding protein 4
Publication Statistics
PubMed Score 5.66
PubMed score by year
PubTator Score 4.43
PubTator score by year
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Related Publications
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PMID
Year
Title