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Tbio
FMO5
Dimethylaniline monooxygenase [N-oxide-forming] 5

Protein Summary
Description
In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme. Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254090
  • ENSP00000254090
  • ENSG00000131781
  • ENST00000369272
  • ENSP00000358277
  • ENST00000441068
  • ENSP00000416011
  • ENST00000578284
  • ENSP00000462062
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
histone modification site profile
0.81
disease perturbation
0.79
protein domain
0.73
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.99   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.99   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.971532429
p_ni:  0.028304475
p_wrong:  0.000163096
Score:  0.359
Data Source:  BioPlex,STRINGDB
ERICH5
Tdark
Novelty:  5.57504212
p_int:  0.941574635
p_ni:  0.048467459
p_wrong:  0.009957906
Score:  0.189
Data Source:  BioPlex,STRINGDB
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.89446851
p_ni:  0.10553149
Data Source:  BioPlex
OGA
Tchem
Family:  Enzyme
Novelty:  0.00035723
p_int:  0.859167292
p_ni:  0.140832708
Score:  0.219
Data Source:  BioPlex,STRINGDB
HERC1
Tbio
Family:  Enzyme
Novelty:  0.04318441
p_int:  0.846790794
p_ni:  0.153209206
Score:  0.165
Data Source:  BioPlex,STRINGDB
CYP3A4
Tclin
Family:  Enzyme
Novelty:  0.00015515
Score:  0.956
Data Source:  STRINGDB
CYP2D6
Tclin
Family:  Enzyme
Novelty:  0.00021853
Score:  0.948
Data Source:  STRINGDB
CYP2C9
Tchem
Novelty:  0.00041914
Score:  0.947
Data Source:  STRINGDB
RB1
Tchem
Novelty:  0.00063798
Score:  0.648
Data Source:  STRINGDB
ACP6
Tbio
Family:  Enzyme
Novelty:  0.04985294
Score:  0.642
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
53.3
granulocyte count
1
1
1
12.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
53.3
granulocyte count
1
12.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
flavin containing monooxygenase 5
VGNC:546
469472
Macaque
flavin containing monooxygenase 5
709691
Mouse
MGI:1310004
14263
Rat
RGD:628602
246248
Dog
flavin containing monooxygenase 5
VGNC:40920
475819
Species
Name
OMA
EggNOG
Inparanoid
Chimp
flavin containing monooxygenase 5
Macaque
flavin containing monooxygenase 5
Mouse
Rat
Dog
flavin containing monooxygenase 5
Publication Statistics
PubMed Score 18.99
PubMed score by year
PubTator Score 25.99
PubTator score by year
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Related Publications
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PMID
Year
Title