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Tbio
FMO4
Dimethylaniline monooxygenase [N-oxide-forming] 4

Protein Summary
Description
This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367749
  • ENSP00000356723
  • ENSG00000076258

Symbol
  • FMO2
  • FMO2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.72
histone modification site profile
0.69
molecular function
0.67
small molecule perturbation
0.67
tissue sample
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.57   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.57   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
FMO1
Tbio
Family:  Enzyme
Novelty:  0.02090294
p_int:  0.998523478
p_ni:  0.000033916
p_wrong:  0.001442606
Score:  0.162
Data Source:  BioPlex,STRINGDB
CYP3A4
Tclin
Family:  Enzyme
Novelty:  0.00015515
Score:  0.946
Data Source:  STRINGDB
CYP2C9
Tchem
Novelty:  0.00041914
Score:  0.932
Data Source:  STRINGDB
CYP2D6
Tclin
Family:  Enzyme
Novelty:  0.00021853
Score:  0.929
Data Source:  STRINGDB
DECR1
Tbio
Family:  Enzyme
Novelty:  0.02699187
Score:  0.66
Data Source:  STRINGDB
UGT2A3
Tbio
Family:  Enzyme
Novelty:  0.08423014
Score:  0.657
Data Source:  STRINGDB
NPR1
Tclin
Family:  Kinase
Novelty:  0.00170829
Score:  0.643
Data Source:  STRINGDB
AAK1
Tchem
Family:  Kinase
Novelty:  0.02438961
Score:  0.529
Data Source:  STRINGDB
CYP3A7
Tclin
Family:  Enzyme
Novelty:  0.00736888
Score:  0.519
Data Source:  STRINGDB
UGT3A1
Tdark
Family:  Enzyme
Novelty:  0.21988583
Score:  0.478
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
49.5
1
1
0
2.8
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
49.5
0
2.8
42.3
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
flavin containing monooxygenase 4
VGNC:545
456443
Macaque
flavin containing monooxygenase 4
704074
Mouse
MGI:2429497
226564
Rat
RGD:628601
246247
Dog
flavin containing monooxygenase 4
VGNC:40919
490345
Species
Name
OMA
EggNOG
Inparanoid
Chimp
flavin containing monooxygenase 4
Macaque
flavin containing monooxygenase 4
Mouse
Rat
Dog
flavin containing monooxygenase 4
Publication Statistics
PubMed Score 24.57
PubMed score by year
PubTator Score 9.33
PubTator score by year
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Related Publications
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PMID
Year
Title