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Tbio
FMO1
Dimethylaniline monooxygenase [N-oxide-forming] 1

Protein Summary
Description
This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines. Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354841
  • ENSP00000346901
  • ENSG00000010932
  • ENST00000367750
  • ENSP00000356724
  • ENST00000402921
  • ENSP00000385543
  • ENST00000617670
  • ENSP00000481732
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
gene perturbation
0.67
molecular function
0.67
pathway
0.67
cellular component
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.64   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.64   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
FMO4
Tbio
Family:  Enzyme
Novelty:  0.0411802
p_int:  0.998523478
p_ni:  0.000033916
p_wrong:  0.001442606
Score:  0.162
Data Source:  BioPlex,STRINGDB
GPRC5C
Tbio
Family:  GPCR
Novelty:  0.16942353
p_int:  0.964132153
p_ni:  0.03586781
p_wrong:  3.7e-8
Data Source:  BioPlex
CYP3A4
Tclin
Family:  Enzyme
Novelty:  0.00015515
Score:  0.963
Data Source:  STRINGDB
CYP2D6
Tclin
Family:  Enzyme
Novelty:  0.00021853
Score:  0.959
Data Source:  STRINGDB
CYP2C9
Tchem
Novelty:  0.00041914
Score:  0.949
Data Source:  STRINGDB
DECR1
Tbio
Family:  Enzyme
Novelty:  0.02699187
Score:  0.733
Data Source:  STRINGDB
CBR3
Tbio
Family:  Enzyme
Novelty:  0.01874422
Score:  0.689
Data Source:  STRINGDB
SULT1C4
Tbio
Family:  Enzyme
Novelty:  0.02556956
Score:  0.65
Data Source:  STRINGDB
NPR1
Tclin
Family:  Kinase
Novelty:  0.00170829
Score:  0.631
Data Source:  STRINGDB
CYP1A2
Tchem
Novelty:  0.00034756
Score:  0.582
Data Source:  STRINGDB
Pathways (8)
Biological oxidations (R-HSA-211859)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
FMO oxidises nucleophiles
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
FMO oxidises nucleophiles
Metabolism
Phase I - Functionalization of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
49.5
1
1
0
2.8
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
49.5
0
2.8
42.3
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
flavin containing monooxygenase 1
VGNC:542
456444
Macaque
flavin containing monooxygenase 1
703743
Mouse
MGI:1310002
14261
Rat
RGD:2622
25256
Dog
flavin containing monooxygenase 1
VGNC:40916
403604
Species
Name
OMA
EggNOG
Inparanoid
Chimp
flavin containing monooxygenase 1
Macaque
flavin containing monooxygenase 1
Mouse
Rat
Dog
flavin containing monooxygenase 1
Publication Statistics
PubMed Score 49.64
PubMed score by year
PubTator Score 52.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title