FMNL1
Formin-like protein 1
Protein Summary
May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
- ENST00000331495
- ENSP00000329219
- ENSG00000184922
- C17orf1
- C17orf1B
- FMNL
- FRL1
- FMNL
- FHOD4
- KW-13
- C17orf1
- C17orf1B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
ligand (protein) perturbation | 0.83 | ||
cellular component | 0.71 | ||
transcription factor | 0.69 | ||
co-expressed gene | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.22 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 155 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.22 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 155 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (107)
PPP1R10
Family: Enzyme
Novelty: 0.01119155
p_int: 0.776960559
p_ni: 0.216566227
p_wrong: 0.006473214
Score: 0.359
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | RHO GTPase Effectors | ||||
Reactome | RHO GTPases Activate Formins | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Rho GTPases | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
RHO GTPase Effectors | ||||
RHO GTPases Activate Formins | ||||
Signal Transduction | ||||
Signaling by Rho GTPases | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (4)
Components (7)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 1 | 4 | 4 | 83.9 | |||||
appendicular lean mass | 2 | 1 | 2 | 80.4 | |||||
body height | 3 | 1 | 3 | 78 | |||||
myeloid white cell count | 1 | 1 | 1 | 67.1 | |||||
platelet crit | 1 | 1 | 1 | 66.8 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 4 | 83.9 | |||||
appendicular lean mass | 2 | 80.4 | |||||
body height | 3 | 78 | |||||
myeloid white cell count | 1 | 67.1 | |||||
platelet crit | 1 | 66.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | formin like 1 | VGNC:9283 | 736805 | |||||
Macaque | formin like 1 | 716211 | ||||||
Mouse | MGI:1888994 | 57778 | ||||||
Rat | RGD:1311042 | 287746 | ||||||
Dog | formin like 1 | VGNC:40914 | 490927 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | formin like 1 | |||||
Macaque | formin like 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | formin like 1 | |||||
Publication Statistics
PubMed Score 43.22
PubMed score by year
PubTator Score 18.99
PubTator score by year
Related Publications
Text Mined References (23)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
|---|