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Tbio
FMN1
Formin-1

Protein Summary
Description
Plays a role in the formation of adherens junction and the polymerization of linear actin cables. This gene belongs to the formin homology family and encodes a protein that has a role in the formation of adherens junction and the polymerization of linear actin cables. The homologous gene in mouse is associated with limb deformity. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320930
  • ENSP00000325166
  • ENSG00000248905
  • ENST00000334528
  • ENSP00000333950
  • ENST00000558197
  • ENSP00000452984
  • ENST00000559047
  • ENSP00000454047
  • ENST00000616417
  • ENSP00000479134
  • ENST00000631469
  • ENSP00000488866
  • ENSG00000282513
  • ENST00000631756
  • ENSP00000488300
  • ENST00000631811
  • ENSP00000488198
  • ENST00000632024
  • ENSP00000488532
  • ENST00000633316
  • ENSP00000487643

Symbol
  • FMN
  • LD
  • LD
  • FMN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
microRNA
0.87
trait
0.86
histone modification site profile
0.67
cell type or tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 748.82   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 748.82   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (201)
CYP2S1
Tbio
Novelty:  0.02967417
p_int:  0.999994376
p_ni:  0.000005624
Score:  0.202
Data Source:  BioPlex,STRINGDB
NAPG
Tbio
Novelty:  0.02295985
p_int:  0.989092455
p_ni:  0.010907538
p_wrong:  7e-9
Score:  0.231
Data Source:  BioPlex,STRINGDB
CDH1
Tbio
Novelty:  0.00010629
Score:  0.938
Data Source:  STRINGDB
CTNNA1
Tbio
Novelty:  0.00925774
Score:  0.937
Data Source:  STRINGDB
CTNND1
Tbio
Novelty:  0.00335459
Score:  0.932
Data Source:  STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.918
Data Source:  STRINGDB
JUP
Tbio
Novelty:  0.0081803
Score:  0.91
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.867
Data Source:  STRINGDB
WDFY4
Tbio
Novelty:  0.15894833
Score:  0.82
Data Source:  STRINGDB
WDFY3
Tbio
Novelty:  0.01670166
Score:  0.807
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
9
0
1.1
97.2
1
5
0
1.1
96.1
hematocrit
2
2
2
82
hemoglobin measurement
2
2
2
77.6
synophrys measurement
1
1
1
76.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
97.2
0
1.1
96.1
hematocrit
2
82
hemoglobin measurement
2
77.6
synophrys measurement
1
76.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 748.82
PubMed score by year
PubTator Score 568.18
PubTator score by year
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Related Publications
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PMID
Year
Title