Protein Summary
Plays a role in the formation of adherens junction and the polymerization of linear actin cables. This gene belongs to the formin homology family and encodes a protein that has a role in the formation of adherens junction and the polymerization of linear actin cables. The homologous gene in mouse is associated with limb deformity. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
- ENST00000320930
- ENSP00000325166
- ENSG00000248905
- ENST00000334528
- ENSP00000333950
- ENST00000558197
- ENSP00000452984
- ENST00000559047
- ENSP00000454047
- ENST00000616417
- ENSP00000479134
- ENST00000631469
- ENSP00000488866
- ENSG00000282513
- ENST00000631756
- ENSP00000488300
- ENST00000631811
- ENSP00000488198
- ENST00000632024
- ENSP00000488532
- ENST00000633316
- ENSP00000487643
- FMN
- LD
- LD
- FMN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.94 | ||
microRNA | 0.87 | ||
trait | 0.86 | ||
histone modification site profile | 0.67 | ||
cell type or tissue | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 748.82 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 92 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 748.82 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 92 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (201)
CYP2S1
Novelty: 0.02967417
p_int: 0.999994376
p_ni: 0.000005624
Score: 0.202
Data Source: BioPlex,STRINGDB
NAPG
Novelty: 0.02295985
p_int: 0.989092455
p_ni: 0.010907538
p_wrong: 7e-9
Score: 0.231
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
PathwayCommons (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: pid | E-cadherin signaling in keratinocytes | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
E-cadherin signaling in keratinocytes | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (3)
Components (5)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
8 | 9 | 0 | 1.1 | 97.2 | |||||
1 | 5 | 0 | 1.1 | 96.1 | |||||
hematocrit | 2 | 2 | 2 | 82 | |||||
hemoglobin measurement | 2 | 2 | 2 | 77.6 | |||||
synophrys measurement | 1 | 1 | 1 | 76.8 | |||||
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 97.2 | |||||
0 | 1.1 | 96.1 | |||||
hematocrit | 2 | 82 | |||||
hemoglobin measurement | 2 | 77.6 | |||||
synophrys measurement | 1 | 76.8 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 748.82
PubMed score by year
PubTator Score 568.18
PubTator score by year
Related Publications
Text Mined References (20)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
|---|