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Tbio
FMC1
Protein FMC1 homolog

Protein Summary
Description
Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) (PubMed:28719601). This locus represents naturally occurring readthrough transcription between the neighboring C7orf55 (chromosome 7 open reading frame 55) and LUC7L2 (LUC7-like 2) genes on chromosome 7. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297534
  • ENSP00000297534
  • ENSG00000164898

Symbol
  • C7orf55
  • FMC1
  • C7orf55
  • C7orf55-LUC7L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.49   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 6   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.49   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 6   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
ATPAF2
Tbio
Family:  Enzyme
Novelty:  0.04184643
p_int:  0.999999801
p_ni:  1.99e-7
Score:  0.96
Data Source:  BioPlex,STRINGDB
FECH
Tchem
Family:  Enzyme
Novelty:  0.00282289
p_int:  0.999927739
p_ni:  0.000072205
p_wrong:  5.6e-8
Score:  0.305
Data Source:  BioPlex,STRINGDB
OXLD1
Tdark
Family:  Enzyme
Novelty:  23
p_int:  0.999912365
p_ni:  0.000087558
p_wrong:  7.7e-8
Score:  0.481
Data Source:  BioPlex,STRINGDB
KLHL22
Tbio
Novelty:  0.24456252
p_int:  0.999674091
p_ni:  0.000325393
p_wrong:  5.15e-7
Data Source:  BioPlex
SLC1A1
Tchem
Family:  Transporter
Novelty:  0.00218479
p_int:  0.999638614
p_ni:  0.000162539
p_wrong:  0.000198846
Data Source:  BioPlex
DLD
Tbio
Family:  Enzyme
Novelty:  0.00214298
p_int:  0.998489121
p_ni:  0.000975379
p_wrong:  0.000535499
Score:  0.185
Data Source:  BioPlex,STRINGDB
SSH3
Tbio
Family:  Enzyme
Novelty:  0.11388661
p_int:  0.998342741
p_ni:  0.001656823
p_wrong:  4.36e-7
Score:  0.164
Data Source:  BioPlex,STRINGDB
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
p_int:  0.997021591
p_ni:  0.001630075
p_wrong:  0.001348334
Score:  0.402
Data Source:  BioPlex,STRINGDB
LIG3
Tbio
Family:  Enzyme
Novelty:  0.00809038
p_int:  0.996180801
p_ni:  0.001664718
p_wrong:  0.002154482
Score:  0.224
Data Source:  BioPlex,STRINGDB
GRPEL2
Tdark
Novelty:  0.52660174
p_int:  0.995078485
p_ni:  0.003366696
p_wrong:  0.001554819
Score:  0.738
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left ventricular diastolic function measurement
1
1
0
1.7
21.5
high density lipoprotein cholesterol measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left ventricular diastolic function measurement
0
1.7
21.5
high density lipoprotein cholesterol measurement
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913367
66117
Rat
RGD:1559476
500087
Horse
formation of mitochondrial complex V assembly factor 1 homolog
VGNC:18070
100066395
Chicken
chromosome 1 C7orf55 homolog
CGNC:8986
770530
Xenopus
formation of mitochondrial complex V assembly factor 1 homolog
XB-GENE-966028
100135156
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
formation of mitochondrial complex V assembly factor 1 homolog
Chicken
chromosome 1 C7orf55 homolog
Xenopus
formation of mitochondrial complex V assembly factor 1 homolog
Publication Statistics
PubMed Score 15.49
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title