FLVCR2
Feline leukemia virus subgroup C receptor-related protein 2
Protein Summary
Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism. This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Aug 2010]
- ENST00000238667
- ENSP00000238667
- ENSG00000119686
- ENST00000539311
- ENSP00000443439
- C14orf58
- CCT
- EPV
- PVHH
- MFSD7C
- SLC49A2
- C14orf58
- FLVCRL14q
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.88 | ||
histone modification site profile | 0.81 | ||
transcription factor binding site profile | 0.66 | ||
transcription factor | 0.64 | ||
tissue | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 67.65 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 113 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 67.65 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 113 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0