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Tbio
FLVCR2
Feline leukemia virus subgroup C receptor-related protein 2

Protein Summary
Description
Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism. This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238667
  • ENSP00000238667
  • ENSG00000119686
  • ENST00000539311
  • ENSP00000443439

Symbol
  • C14orf58
  • CCT
  • EPV
  • PVHH
  • MFSD7C
  • SLC49A2
  • C14orf58
  • FLVCRL14q
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
histone modification site profile
0.81
transcription factor binding site profile
0.66
transcription factor
0.64
tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.65   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.65   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
EPN1
Tbio
Novelty:  0.01788784
p_int:  0.98990895
p_ni:  0.01009064
p_wrong:  4.1e-7
Score:  0.382
Data Source:  BioPlex,STRINGDB
GLYAT
Tbio
Family:  Enzyme
Novelty:  0.02347543
Score:  0.832
Data Source:  STRINGDB
TSHZ1
Tbio
Family:  TF
Novelty:  0.02155224
Score:  0.817
Data Source:  STRINGDB
GUCY2C
Tclin
Family:  Kinase
Novelty:  0.00209733
Score:  0.8
Data Source:  STRINGDB
GCA
Tbio
Novelty:  0.01485875
Score:  0.796
Data Source:  STRINGDB
GGCT
Tchem
Family:  Enzyme
Novelty:  0.01154389
Score:  0.796
Data Source:  STRINGDB
GAA
Tclin
Family:  Enzyme
Novelty:  0.0063246
Score:  0.794
Data Source:  STRINGDB
MPG
Tchem
Family:  Enzyme
Novelty:  0.00373538
Score:  0.791
Data Source:  STRINGDB
AGA
Tbio
Family:  Enzyme
Novelty:  0.01522819
Score:  0.79
Data Source:  STRINGDB
DOCK11
Tdark
Novelty:  0.0295159
Score:  0.788
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
3
3
0
1.1
86.4
lymphocyte count
4
2
4
73.7
appendicular lean mass
1
1
1
49.3
1
1
0
1.2
45.7
eosinophil count
6
1
6
29.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
0
1.1
86.4
lymphocyte count
4
73.7
appendicular lean mass
1
49.3
0
1.2
45.7
eosinophil count
6
29.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
feline leukemia virus subgroup C cellular receptor family member 2
VGNC:7440
453050
Macaque
feline leukemia virus subgroup C cellular receptor family member 2
702759
Mouse
MGI:2384974
217721
Rat
RGD:735098
314323
Dog
feline leukemia virus subgroup C cellular receptor family member 2
490795
Species
Name
OMA
EggNOG
Inparanoid
Chimp
feline leukemia virus subgroup C cellular receptor family member 2
Macaque
feline leukemia virus subgroup C cellular receptor family member 2
Mouse
Rat
Dog
feline leukemia virus subgroup C cellular receptor family member 2
Publication Statistics
PubMed Score 67.65
PubMed score by year
PubTator Score 10.23
PubTator score by year
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Related Publications
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PMID
Year
Title