You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FLRT3
Leucine-rich repeat transmembrane protein FLRT3

Protein Summary
Description
Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:26235030). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (PubMed:14706654). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor- ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341420
  • ENSP00000339912
  • ENSG00000125848
  • ENST00000378053
  • ENSP00000367292

Symbol
  • KIAA1469
  • HH21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.87
transcription factor perturbation
0.84
microRNA
0.82
virus perturbation
0.79
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.57   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.57   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
MBLAC2
Tdark
Family:  Enzyme
Novelty:  0.47407992
p_int:  0.999993619
p_ni:  2.34e-7
p_wrong:  0.000006147
Score:  0.204
Data Source:  BioPlex,STRINGDB
FLRT1
Tdark
Novelty:  0.23047852
p_int:  0.999993227
p_ni:  1e-9
p_wrong:  0.000006772
Score:  0.37
Data Source:  BioPlex,STRINGDB
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
Score:  0.99
Data Source:  STRINGDB
ROBO1
Tbio
Novelty:  0.00494884
Score:  0.941
Data Source:  Reactome,STRINGDB
FGF6
Tbio
Novelty:  0.021785
Score:  0.912
Data Source:  STRINGDB
FGF22
Tbio
Novelty:  0.0553003
Score:  0.911
Data Source:  STRINGDB
FGF10
Tbio
Novelty:  0.00217451
Score:  0.911
Data Source:  STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.91
Data Source:  STRINGDB
FGF9
Tbio
Novelty:  0.003428
Score:  0.91
Data Source:  STRINGDB
FGF2
Tchem
Novelty:  0.00007856
Score:  0.91
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Downstream signaling of activated FGFR1
Reactome
Signal Transduction
Reactome
Signaling by FGFR
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Downstream signaling of activated FGFR1
Signal Transduction
Signaling by FGFR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibronectin leucine rich transmembrane protein 3
VGNC:9860
469886
Macaque
fibronectin leucine rich transmembrane protein 3
694694
Mouse
MGI:1918686
71436
Rat
RGD:1566005
366205
Dog
fibronectin leucine rich transmembrane protein 3
VGNC:40906
477149
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibronectin leucine rich transmembrane protein 3
Macaque
fibronectin leucine rich transmembrane protein 3
Mouse
Rat
Dog
fibronectin leucine rich transmembrane protein 3
Publication Statistics
PubMed Score 20.57
PubMed score by year
PubTator Score 10.41
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title