Tbio FLOT2 Flotillin-2

Protein Summary

Description

May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function. Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q14254

Gene Name

• FLOT2

Ensembl ID

• ENST00000394908
• ENSP00000378368
• ENSG00000132589

Symbol

• ESA1
• M17S1
• ESA
• ECS1
• ESA1
• ECS-1
• M17S1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.96
transcription factor perturbation	0.91
kinase perturbation	0.88
cellular component	0.79
interacting protein	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.27   (req: < 5)

Gene RIFs: 54   (req: <= 3)

Antibodies: 285   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.27   (req: >= 5)

Gene RIFs: 54   (req: > 3)

Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (72)

Explore Interacting Targets

1 – 10 of 72

• See Interactions on String-DB

TMEM79

Tbio

Novelty:  0.0624393

p_int:  0.999999991

p_ni:  9e-9

Score:  0.359

Data Source:  BioPlex,STRINGDB

MPC2

Tbio

Novelty:  0.02948696

p_int:  0.975256648

p_ni:  0.02474268

p_wrong:  6.71e-7

Score:  0.513

Data Source:  BioPlex,STRINGDB

GORASP2

Tbio

Novelty:  0.02121907

p_int:  0.899605181

p_ni:  0.100394819

Score:  0.221

Data Source:  BioPlex,STRINGDB

TBC1D15

Tbio

Novelty:  0.11296513

p_int:  0.883494323

p_ni:  0.116505674

p_wrong:  3e-9

Score:  0.252

Data Source:  BioPlex,STRINGDB

MPZL3

Tbio

Novelty:  0.25092947

p_int:  0.857821909

p_ni:  6.9e-8

p_wrong:  0.142178022

Score:  0.689

Data Source:  BioPlex,STRINGDB

CAV1

Tbio

Novelty:  0.00035244

Score:  0.971

Data Source:  STRINGDB

FLOT1

Tbio

Novelty:  0.00504569

Score:  0.968

Data Source:  STRINGDB

CDH1

Tbio

Novelty:  0.00010629

Score:  0.92

Data Source:  STRINGDB

LRFN3

Tdark

Novelty:  0.30018245

Score:  0.905

Data Source:  Reactome,STRINGDB

SLC6A3

Tclin

Family:  Transporter

Novelty:  0.00017601

Score:  0.903

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (9)

Reactome (3)

KEGG (1)

PathwayCommons (3)

WikiPathways (2)

Neuronal System (R-HSA-112316)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Neuronal System	398 targets	R-HSA-112316
Reactome	Protein-protein interactions at synapses	91 targets	R-HSA-6794362
Reactome	Synaptic adhesion-like molecules	21 targets	R-HSA-8849932

Name	Explore in Pharos	Explore in Source
Neuronal System	398 targets	R-HSA-112316
Protein-protein interactions at synapses	91 targets	R-HSA-6794362
Synaptic adhesion-like molecules	21 targets	R-HSA-8849932

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (35)

Functions (3)

Components (20)

Processes (12)

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GO Term	Evidence	Assigned by
protein heterodimerization activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
ionotropic glutamate receptor binding	Inferred from Electronic Annotation (IEA)	Ensembl
protease binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (19)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 19

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	5	5	5		98.9
red blood cell distribution width	EFO_0005192	4	4	4		98.8
reticulocyte count	EFO_0007986	4	3	4		94
reticulocyte measurement	EFO_0010700	2	2	2		89.1
hemoglobin measurement	EFO_0004509	2	2	2		84.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 19

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	5		98.9
red blood cell distribution width	EFO_0005192	4		98.8
reticulocyte count	EFO_0007986	4		94
reticulocyte measurement	EFO_0010700	2		89.1
hemoglobin measurement	EFO_0004509	2		84.3

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UniProt Keyword Find Similar Targets

No Header	No Header
Cell adhesion
Cell membrane
Complete proteome
Endosome
Lipoprotein
Membrane
Myristate
Palmitate
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
cigarettes per day measurement
cognitive function measurement
erythrocyte count
HbA1c measurement
hemoglobin measurement
insomnia measurement
mathematical ability
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
mean corpuscular volume

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	flotillin 2	VGNC:9433	454537
Macaque	flotillin 2		716527
Mouse	flotillin 2	MGI:103309	14252
Rat	flotillin 2	RGD:70993	83764
Horse	flotillin 2	VGNC:18064	100072090

Species	Name	OMA	EggNOG	Inparanoid
Chimp	flotillin 2
Macaque	flotillin 2
Mouse	flotillin 2
Rat	flotillin 2
Horse	flotillin 2

Publication Statistics

PubMed Score 141.27

PubMed score by year

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PubTator Score 95.95

PubTator score by year

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Related Publications

Text Mined References (83)

GeneRif Annotations (54)

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PMID	Year	Title