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Tbio
FLNA
Filamin-A

Protein Summary
Description
Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encode ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360319
  • ENSP00000353467
  • ENSG00000196924
  • ENST00000369850
  • ENSP00000358866
  • ENST00000422373
  • ENSP00000416926

Symbol
  • FLN
  • FLN1
  • FLN
  • FMD
  • MNS
  • OPD
  • ABPX
  • CSBS
  • CVD1
  • FGS2
  • FLN1
  • NHBP
  • OPD1
  • OPD2
  • XLVD
  • XMVD
  • FLN-A
  • ABP-280
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
interacting protein
1
protein complex
1
molecular function
0.99


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 895.09   (req: < 5)
Gene RIFs: 204   (req: <= 3)
Antibodies: 586   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 895.09   (req: >= 5)
Gene RIFs: 204   (req: > 3)
Antibodies: 586   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0