Protein Summary
Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encode ...more
- ENST00000360319
- ENSP00000353467
- ENSG00000196924
- ENST00000369850
- ENSP00000358866
- ENST00000422373
- ENSP00000416926
- FLN
- FLN1
- FLN
- FMD
- MNS
- OPD
- ABPX
- CSBS
- CVD1
- FGS2
- FLN1
- NHBP
- OPD1
- OPD2
- XLVD
- XMVD
- FLN-A
- ABP-280
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
hub protein | 1 | ||
interacting protein | 1 | ||
protein complex | 1 | ||
molecular function | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 737.96 (req: < 5)
Gene RIFs: 204 (req: <= 3)
Antibodies: 586 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 737.96 (req: >= 5)
Gene RIFs: 204 (req: > 3)
Antibodies: 586 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 55
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (289)
HSPB7
Novelty: 0.03344805
p_int: 0.999476352
p_ni: 0.000523648
Score: 0.949
Data Source: BioPlex,STRINGDB
NUDT5
Family: Enzyme
Novelty: 0.02550535
p_int: 0.999424629
p_ni: 0.000575372
Data Source: BioPlex
FAM90A1
Novelty: 0.95155075
p_int: 0.994417952
p_ni: 0.005582048
Score: 0.234
Data Source: BioPlex,STRINGDB
FBLIM1
Novelty: 0.0332985
p_int: 0.976527727
p_ni: 0.023472273
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CAPN6
Novelty: 0.04489237
p_int: 0.943511427
p_ni: 0.056488573
Score: 0.329
Data Source: BioPlex,STRINGDB
APOH
Novelty: 0.00049117
p_int: 0.921516266
p_ni: 0.078483734
Score: 0.485
Data Source: BioPlex,STRINGDB
RAB8B
Family: Enzyme
Novelty: 0.06230082
p_int: 0.783698843
p_ni: 0.216301157
Score: 0.355
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (4)
Upstream (4)
1 – 4 of 4
Pathways (47)
Reactome (17)
KEGG (4)
PathwayCommons (9)
WikiPathways (17)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-extracellular matrix interactions | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Antiviral mechanism by IFN-stimulated genes | ||||
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-extracellular matrix interactions | ||||
Cytokine Signaling in Immune system | ||||
Viral Interactions (0)
Gene Ontology Terms (76)
Functions (17)
Components (21)
Processes (38)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 3 | 3 | 91.4 | |||||
reticulocyte count | 2 | 2 | 2 | 89.6 | |||||
leukocyte count | 1 | 1 | 1 | 72.5 | |||||
sex hormone-binding globulin measurement | 3 | 2 | 3 | 57.7 | |||||
bilirubin measurement | 1 | 1 | 1 | 26.1 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 91.4 | |||||
reticulocyte count | 2 | 89.6 | |||||
leukocyte count | 1 | 72.5 | |||||
sex hormone-binding globulin measurement | 3 | 57.7 | |||||
bilirubin measurement | 1 | 26.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | filamin A | 699524 | ||||||
Mouse | MGI:95556 | 192176 | ||||||
Rat | RGD:1560614 | 293860 | ||||||
Dog | filamin A | VGNC:40900 | 481084 | |||||
Horse | filamin A | VGNC:18060 | 100058256 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | filamin A | |||||
Mouse | ||||||
Rat | ||||||
Dog | filamin A | |||||
Horse | filamin A | |||||
Publication Statistics
PubMed Score 737.96
PubMed score by year
PubTator Score 464.10
PubTator score by year
Related Publications
Text Mined References (318)
GeneRif Annotations (204)
Items per page:
0 of 0
PMID | Year | Title |
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