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Tbio
FLG2
Filaggrin-2

Protein Summary
Description
The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000388718
  • ENSP00000373370
  • ENSG00000143520

Symbol
  • IFPS
  • IFPS
  • PSS6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
protein domain
0.85
protein complex
0.84
cell type or tissue
0.82
cell line
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.91   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.91   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
CAMP
Tbio
Novelty:  0.00064433
Score:  0.917
Data Source:  STRINGDB
GSDMD
Tchem
Novelty:  0.00500354
Score:  0.912
Data Source:  STRINGDB
CTSD
Tchem
Family:  Enzyme
Novelty:  0.00029823
Score:  0.906
Data Source:  STRINGDB
CRISP3
Tbio
Novelty:  0.017452
Score:  0.905
Data Source:  STRINGDB
TIMP2
Tbio
Family:  Enzyme
Novelty:  0.00064016
Score:  0.904
Data Source:  STRINGDB
PGLYRP1
Tbio
Novelty:  0.00231527
Score:  0.903
Data Source:  STRINGDB
CFP
Tbio
Novelty:  0.00063251
Score:  0.902
Data Source:  STRINGDB
PRG3
Tbio
Novelty:  0.09431986
Score:  0.902
Data Source:  STRINGDB
CXCL1
Tbio
Novelty:  0.00059123
Score:  0.902
Data Source:  STRINGDB
PGM1
Tbio
Family:  Enzyme
Novelty:  0.00163947
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
11
13
99.1
5
2
2
1.2
94.6
7
2
0
1.3
91.8
age at onset
1
1
1
86.8
childhood onset asthma
1
1
0
2
85.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
13
99.1
2
1.2
94.6
0
1.3
91.8
age at onset
1
86.8
childhood onset asthma
0
2
85.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
filaggrin family member 2
VGNC:10642
100614947
Macaque
filaggrin family member 2
717480
Mouse
MGI:3645678
229574
Pig
filaggrin family member 2 [Source:HGNC Symbol;Acc:HGNC:33276]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
filaggrin family member 2
Macaque
filaggrin family member 2
Mouse
Pig
filaggrin family member 2 [Source:HGNC Symbol;Acc:HGNC:33276]
Publication Statistics
PubMed Score 33.91
PubMed score by year
PubTator Score 16.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title