Tbio FLG Filaggrin

Protein Summary

Description

Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]

Uniprot Accession IDs

• P20930
• Q01720
• Q5T583
• Q9UC71

Gene Name

• FLG

Ensembl ID

• ENST00000368799
• ENSP00000357789
• ENSG00000143631

Symbol

• ATOD2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.95
protein domain	0.85
cellular component	0.68
cell type or tissue	0.65
phenotype	0.63

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Filaggrin

DTO Classes

Protein / Cellular Structure / Filaggrin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1671.25   (req: < 5)

Gene RIFs: 286   (req: <= 3)

Antibodies: 510   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1671.25   (req: >= 5)

Gene RIFs: 286   (req: > 3)

Antibodies: 510   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0