Protein Summary
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
- ENST00000368799
- ENSP00000357789
- ENSG00000143631
- ATOD2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.95 | ||
protein domain | 0.85 | ||
cellular component | 0.68 | ||
cell type or tissue | 0.65 | ||
phenotype | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1467.5 (req: < 5)
Gene RIFs: 286 (req: <= 3)
Antibodies: 510 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1467.5 (req: >= 5)
Gene RIFs: 286 (req: > 3)
Antibodies: 510 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (149)
PI4KA
Family: Kinase
Novelty: 0.01701469
p_int: 0.975321724
p_ni: 0.024678276
Data Source: BioPlex
CFAP298
Novelty: 0.1550579
p_int: 0.912578562
p_ni: 0.087421438
Score: 0.159
Data Source: BioPlex,STRINGDB
STK16
Family: Kinase
Novelty: 0.01499094
p_int: 0.839456504
p_ni: 0.160543496
Score: 0.188
Data Source: BioPlex,STRINGDB
UCP2
Novelty: 0.00083843
p_int: 0.778361634
p_ni: 0.221638365
p_wrong: 1e-9
Score: 0.19
Data Source: BioPlex,STRINGDB
ZSCAN12
Family: TF
Novelty: 0.33578207
p_int: 0.750159016
p_ni: 0.249840984
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (4)
Components (7)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | CAFA | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
vitamin D measurement | 3 | 12 | 15 | 99.1 | |||||
5 | 3 | 4 | 1.2 | 97.2 | |||||
age at onset | 2 | 2 | 2 | 1.3 | 94.6 | ||||
8 | 3 | 0 | 1.2 | 94.4 | |||||
childhood onset asthma | 2 | 2 | 0 | 1.6 | 93.9 | ||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
vitamin D measurement | 15 | 99.1 | |||||
4 | 1.2 | 97.2 | |||||
age at onset | 2 | 1.3 | 94.6 | ||||
0 | 1.2 | 94.4 | |||||
childhood onset asthma | 0 | 1.6 | 93.9 | ||||
Find similar targets by:
IDG Resources
Orthologs (1)
1 – 1 of 1
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | filaggrin | VGNC:541 | 104002779 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | filaggrin | |||||
Publication Statistics
PubMed Score 1467.50
PubMed score by year
PubTator Score 756.97
PubTator score by year
Related Publications
Text Mined References (322)
GeneRif Annotations (286)
Items per page:
0 of 0
PMID | Year | Title |
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