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Tbio
FKTN
Fukutin

Protein Summary
Description
Catalyzes the transfer of CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:17034757, PubMed:25279699, PubMed:26923585, PubMed:29477842). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (PubMed:17034757, PubMed:25279699, PubMed:26923585, PubMed:29477842). Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity (PubMed:17034757). May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes (PubMed:25279699). Could be involved in brain development (Probable). The protein encoded by this gene is a putative transmembrane protein t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223528
  • ENSP00000223528
  • ENSG00000106692
  • ENST00000357998
  • ENSP00000350687
  • ENST00000448551
  • ENSP00000399140
  • ENST00000602661
  • ENSP00000473540

Symbol
  • FCMD
  • FCMD
  • CMD1X
  • LGMD2M
  • MDDGA4
  • MDDGB4
  • MDDGC4
  • LGMDR13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
cellular component
0.77
microRNA
0.69
kinase perturbation
0.66
biological process
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.42   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.42   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
RXYLT1
Tbio
Novelty:  0.14843707
p_int:  0.999970201
p_ni:  0.000029797
p_wrong:  2e-9
Score:  0.852
Data Source:  BioPlex,STRINGDB
HLA-DPA1
Tbio
Novelty:  0.01080446
p_int:  0.999699196
p_ni:  0.000300794
p_wrong:  1e-8
Score:  0.185
Data Source:  BioPlex,STRINGDB
B4GAT1
Tbio
Family:  Enzyme
Novelty:  0.14959923
p_int:  0.996995565
p_ni:  0.002887084
p_wrong:  0.000117351
Score:  0.679
Data Source:  BioPlex,STRINGDB
FKRP
Tbio
Novelty:  0.00798137
Score:  0.992
Data Source:  STRINGDB
ISPD
Tbio
Family:  Enzyme
Novelty:  0.01137456
Score:  0.991
Data Source:  STRINGDB
POMK
Tbio
Family:  Kinase
Novelty:  0.09340344
Score:  0.977
Data Source:  STRINGDB
POMGNT1
Tbio
Family:  Enzyme
Novelty:  0.00755927
Score:  0.958
Data Source:  STRINGDB
POMT1
Tbio
Family:  Enzyme
Novelty:  0.01971429
Score:  0.952
Data Source:  STRINGDB
POMT2
Tbio
Family:  Enzyme
Novelty:  0.0251595
Score:  0.95
Data Source:  STRINGDB
DAG1
Tbio
Family:  Enzyme
Novelty:  0.00149278
Score:  0.87
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fukutin
VGNC:4737
464634
Macaque
fukutin
712201
Mouse
MGI:2179507
246179
Rat
RGD:1310087
362520
Dog
fukutin
VGNC:40897
481652
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fukutin
Macaque
fukutin
Mouse
Rat
Dog
fukutin
Publication Statistics
PubMed Score 244.42
PubMed score by year
PubTator Score 203.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title