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Tbio
FKBPL
FK506-binding protein-like

Protein Summary
Description
May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21. The protein encoded by this gene has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375156
  • ENSP00000364298
  • ENSG00000204315
  • ENST00000425378
  • ENSP00000397530
  • ENSG00000230907
  • ENST00000443350
  • ENSP00000398812
  • ENSG00000223666
  • ENST00000456854
  • ENSP00000412439
  • ENSG00000224200

Symbol
  • DIR1
  • NG7
  • NG7
  • DIR1
  • FKBP4
  • WISP39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
protein domain
0.73
disease perturbation
0.68
transcription factor binding site profile
0.68
tissue sample
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.59   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.59   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
ANKRD49
Tbio
Novelty:  0.00254346
p_int:  1
Score:  0.87
Data Source:  BioPlex,STRINGDB
NADSYN1
Tbio
Family:  Enzyme
Novelty:  0.0445844
p_int:  0.999997595
p_ni:  1.96e-7
p_wrong:  0.000002209
Score:  0.297
Data Source:  BioPlex,STRINGDB
RBCK1
Tbio
Novelty:  0.02760333
p_int:  0.999954158
p_ni:  0.000037712
p_wrong:  0.000008129
Score:  0.765
Data Source:  BioPlex,STRINGDB
BRAF
Tclin
Family:  Kinase
Novelty:  0.00253795
p_int:  0.999448956
p_ni:  0.000551004
p_wrong:  3.9e-8
Score:  0.23
Data Source:  BioPlex,STRINGDB
RNF31
Tbio
Family:  Enzyme
Novelty:  0.01394304
p_int:  0.996798311
p_ni:  0.00319174
p_wrong:  0.000009949
Score:  0.42
Data Source:  BioPlex,STRINGDB
CSNK1E
Tclin
Family:  Kinase
Novelty:  0.00891859
p_int:  0.985084914
p_ni:  0.014915086
Score:  0.477
Data Source:  BioPlex,STRINGDB
PLS1
Tbio
Novelty:  0.00538817
p_int:  0.983926715
p_ni:  0.016073279
p_wrong:  6e-9
Score:  0.168
Data Source:  BioPlex,STRINGDB
EDRF1
Tbio
Novelty:  0.24333657
p_int:  0.982629749
p_ni:  0.017370178
p_wrong:  7.3e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
CSNK1D
Tchem
Family:  Kinase
Novelty:  0.00896935
p_int:  0.980951397
p_ni:  0.0190486
p_wrong:  3e-9
Score:  0.68
Data Source:  BioPlex,STRINGDB
CTU1
Tbio
Novelty:  0.04670058
p_int:  0.760820341
p_ni:  0.230146926
p_wrong:  0.009032733
Score:  0.252
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
G2/M Transition
Reactome
Mitotic G2-G2/M phases
Reactome
The role of GTSE1 in G2/M progression after G2 checkpoint
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
G2/M Transition
Mitotic G2-G2/M phases
The role of GTSE1 in G2/M progression after G2 checkpoint
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (240)
Items per page:
1 – 5 of 240
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
complement C4 measurement
2
6
10
98.5
complement C4 measurement
2
6
10
98.5
complement C4 measurement
2
6
10
98.5
4
3
0
2.3
97.6
4
3
0
2.3
97.6
Items per page:
1 – 5 of 240
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
complement C4 measurement
10
98.5
complement C4 measurement
10
98.5
complement C4 measurement
10
98.5
0
2.3
97.6
0
2.3
97.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FK506 binding protein like
VGNC:11079
745752
Macaque
FK506 binding protein like
717079
Mouse
MGI:1932127
56299
Rat
RGD:1303227
406168
Cow
FK506 binding protein like
VGNC:29028
513929
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FK506 binding protein like
Macaque
FK506 binding protein like
Mouse
Rat
Cow
FK506 binding protein like
Publication Statistics
PubMed Score 52.59
PubMed score by year
PubTator Score 39.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title