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Tbio
FKBPL
FK506-binding protein-like

Protein Summary
Description
May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21. The protein encoded by this gene has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375156
  • ENSP00000364298
  • ENSG00000204315
  • ENST00000425378
  • ENSP00000397530
  • ENSG00000230907
  • ENST00000443350
  • ENSP00000398812
  • ENSG00000223666
  • ENST00000456854
  • ENSP00000412439
  • ENSG00000224200

Symbol
  • DIR1
  • NG7
  • NG7
  • DIR1
  • FKBP4
  • WISP39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
protein domain
0.73
disease perturbation
0.68
transcription factor binding site profile
0.68
tissue sample
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.3   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.3   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0