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Tchem
FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

Protein Summary
Description
Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357266
  • ENSP00000349811
  • ENSG00000096060
  • ENST00000536438
  • ENSP00000444810
  • ENST00000539068
  • ENSP00000441205
  • ENST00000542713
  • ENSP00000442340

Symbol
  • AIG6
  • FKBP51
  • P54
  • AIG6
  • FKBP51
  • FKBP54
  • PPIase
  • Ptg-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
protein domain
0.92
transcription factor perturbation
0.91
biological term
0.88
small molecule perturbation
0.86


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 684.96   (req: < 5)
Gene RIFs: 204   (req: <= 3)
Antibodies: 411   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 684.96   (req: >= 5)
Gene RIFs: 204   (req: > 3)
Antibodies: 411   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 55
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2