Tbio FKBP11 Peptidyl-prolyl cis-trans isomerase FKBP11

Protein Summary

Description

PPIases accelerate the folding of proteins during protein synthesis. FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9NYL4
• B4DWB7
• PPIase FKBP11

Gene Name

• FKBP11

Ensembl ID

• ENST00000453172
• ENSP00000396874
• ENSG00000134285
• ENST00000550765
• ENSP00000449751

Symbol

• FKBP19
• FKBP19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
histone modification site profile	0.76
kinase perturbation	0.71
gene perturbation	0.68
small molecule perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.26   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 186   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.26   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0