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Tbio
FJX1
Four-jointed box protein 1

Protein Summary
Description
Acts as an inhibitor of dendrite extension and branching. The protein encoded by this gene is the human ortholog of mouse and Drosophila four-jointed gene product. The Drosophila protein is important for growth and differentiation of legs and wings, and for proper development of the eyes. The exact function of this gene in humans is not known. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317811
  • ENSP00000400223
  • ENSG00000179431
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
kinase perturbation
0.88
PubMedID
0.85
transcription factor binding site profile
0.76
disease perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.24   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.24   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
FAT4
Tbio
Novelty:  0.01739918
Score:  0.97
Data Source:  STRINGDB
COMMD9
Tdark
Novelty:  0.77223999
Score:  0.904
Data Source:  STRINGDB
TRIM44
Tbio
Novelty:  0.00483553
Score:  0.845
Data Source:  STRINGDB
DCHS1
Tbio
Novelty:  0.02220058
Score:  0.792
Data Source:  STRINGDB
DCHS2
Tdark
Novelty:  0.20559245
Score:  0.791
Data Source:  STRINGDB
FAM198A
Tdark
Novelty:  0.65293749
Score:  0.784
Data Source:  STRINGDB
FAM198B
Tbio
Novelty:  0.16692868
Score:  0.755
Data Source:  STRINGDB
FAM20B
Tdark
Family:  Enzyme
Novelty:  0.07347685
Score:  0.719
Data Source:  STRINGDB
VANGL2
Tbio
Novelty:  0.00529796
Score:  0.708
Data Source:  STRINGDB
FAM20A
Tbio
Family:  Enzyme
Novelty:  0.03742119
Score:  0.708
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autosomal dominant compelling helio-ophthalmic outburst syndrome
1
1
0
1.1
52.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autosomal dominant compelling helio-ophthalmic outburst syndrome
0
1.1
52.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
four jointed box 1
VGNC:1058
451124
Mouse
MGI:1341907
14221
Rat
RGD:1306113
366140
Dog
four jointed box 1
VGNC:40886
483425
Pig
four jointed box 1
100626682
Species
Name
OMA
EggNOG
Inparanoid
Chimp
four jointed box 1
Mouse
Rat
Dog
four jointed box 1
Pig
four jointed box 1
Publication Statistics
PubMed Score 18.24
PubMed score by year
PubTator Score 3.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title