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Tdark
FITM2
Fat storage-inducing transmembrane protein 2

Protein Summary
Description
Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization. FIT2 belongs to an evolutionarily conserved family of proteins involved in fat storage (Kadereit et al., 2008 [PubMed 18160536]).[supplied by OMIM, May 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396825
  • ENSP00000380037
  • ENSG00000197296

Symbol
  • C20orf142
  • FIT2
  • Fit2
  • C20orf142
  • dJ881L22.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.83
cellular component
0.74
transcription factor perturbation
0.74
kinase perturbation
0.71
small molecule perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.76   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 10   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.76   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 10   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.995783002
p_ni:  0.004216801
p_wrong:  1.97e-7
Data Source:  BioPlex
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.994738763
p_ni:  0.005261148
p_wrong:  8.9e-8
Data Source:  BioPlex
GPM6A
Tbio
Novelty:  0.04123799
p_int:  0.994222402
p_ni:  0.005777292
p_wrong:  3.05e-7
Score:  0.309
Data Source:  BioPlex,STRINGDB
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.977168673
p_ni:  0.022816335
p_wrong:  0.000014993
Data Source:  BioPlex
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.976929043
p_ni:  0.023069745
p_wrong:  0.000001212
Data Source:  BioPlex
TSPAN31
Tbio
Novelty:  0.13580467
p_int:  0.97546239
p_ni:  0.023321671
p_wrong:  0.001215939
Data Source:  BioPlex
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
p_int:  0.974254006
p_ni:  0.024499822
p_wrong:  0.001246172
Data Source:  BioPlex
GPR52
Tchem
Family:  GPCR
Novelty:  0.07988639
p_int:  0.971651013
p_ni:  0.02833541
p_wrong:  0.000013578
Data Source:  BioPlex
SLC7A1
Tbio
Family:  Transporter
Novelty:  0.00197313
p_int:  0.968475129
p_ni:  0.031509993
p_wrong:  0.000014878
Data Source:  BioPlex
CDHR5
Tbio
Novelty:  0.08525208
p_int:  0.962181618
p_ni:  0.037802297
p_wrong:  0.000016085
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Lipid particle organization (R-HSA-8964572)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Lipid particle organization
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Lipid particle organization
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
11
7
4
1.1
94.5
monocyte count
2
2
2
90.4
granulocyte percentage of myeloid white cells
1
2
2
84.7
monocyte percentage of leukocytes
2
2
3
84.3
mean corpuscular volume
1
2
2
79.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
94.5
monocyte count
2
90.4
granulocyte percentage of myeloid white cells
2
84.7
monocyte percentage of leukocytes
3
84.3
mean corpuscular volume
2
79.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fat storage inducing transmembrane protein 2
VGNC:9859
458268
Mouse
MGI:2444508
228859
Rat
RGD:1307696
311617
Dog
fat storage inducing transmembrane protein 2
VGNC:54304
485882
Horse
fat storage inducing transmembrane protein 2
VGNC:51537
100147308
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fat storage inducing transmembrane protein 2
Mouse
Rat
Dog
fat storage inducing transmembrane protein 2
Horse
fat storage inducing transmembrane protein 2
Publication Statistics
PubMed Score 59.76
PubMed score by year
PubTator Score 36.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title