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Tbio
FIP1L1
Pre-mRNA 3'-end-processing factor FIP1

Protein Summary
Description
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth facto ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306932
  • ENSP00000302993
  • ENSG00000145216
  • ENST00000337488
  • ENSP00000336752
  • ENST00000358575
  • ENSP00000351383
  • ENST00000507922
  • ENSP00000425456

Symbol
  • FIP1
  • RHE
  • Rhe
  • FIP1
  • hFip1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
ligand (protein) perturbation
0.96
transcription factor perturbation
0.88
tissue
0.69
virus perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.88   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.88   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (302)
CPSF4
Tbio
Novelty:  0.00206207
p_int:  0.999943125
p_ni:  0.000056875
Score:  0.999
Data Source:  BioPlex,STRINGDB
P4HA1
Tchem
Family:  Enzyme
Novelty:  0.01624726
p_int:  0.997276207
p_ni:  0.002723793
Score:  0.211
Data Source:  BioPlex,STRINGDB
P4HA2
Tbio
Family:  Enzyme
Novelty:  0.02097718
p_int:  0.99625152
p_ni:  0.003748481
Score:  0.762
Data Source:  BioPlex,STRINGDB
CPSF2
Tbio
Novelty:  0.0510853
p_int:  0.993022404
p_ni:  0.006977597
Score:  0.998
Data Source:  BioPlex,STRINGDB
CPSF4L
Tdark
Novelty:  4.27116708
p_int:  0.926602137
p_ni:  0.073397863
Score:  0.957
Data Source:  BioPlex,STRINGDB
ZC3H18
Tdark
Novelty:  0.3515546
p_int:  0.880800261
p_ni:  0.119199739
Score:  0.318
Data Source:  BioPlex,STRINGDB
WDR33
Tbio
Novelty:  0.09221439
Score:  0.999
Data Source:  STRINGDB
CPSF1
Tbio
Novelty:  0.04396897
Score:  0.999
Data Source:  STRINGDB
CPSF3
Tchem
Novelty:  0.01880576
Score:  0.999
Data Source:  STRINGDB
PCF11
Tbio
Novelty:  0.01882626
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Gene expression (Transcription) (R-HSA-74160)

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Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Reactome
Processing of Intronless Pre-mRNAs
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Processing of Intronless Pre-mRNAs
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
72.3
neutrophil count
1
1
1
50.6
1
1
0
2.2
36.9
cervical artery dissection
1
1
0
1.2
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
72.3
neutrophil count
1
50.6
0
2.2
36.9
cervical artery dissection
0
1.2
21.5
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
factor interacting with PAPOLA and CPSF1
VGNC:603
107974320
Macaque
platelet derived growth factor receptor alpha [Source:HGNC Symbol;Acc:HGNC:8803]
Mouse
MGI:1914149
66899
Rat
RGD:1309336
289582
Dog
factor interacting with PAPOLA and CPSF1
VGNC:40883
612980
Species
Name
OMA
EggNOG
Inparanoid
Chimp
factor interacting with PAPOLA and CPSF1
Macaque
platelet derived growth factor receptor alpha [Source:HGNC Symbol;Acc:HGNC:8803]
Mouse
Rat
Dog
factor interacting with PAPOLA and CPSF1
Publication Statistics
PubMed Score 203.88
PubMed score by year
PubTator Score 212.40
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title