Tbio FIP1L1 Pre-mRNA 3'-end-processing factor FIP1

Protein Summary

Description

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q6UN15
• B4DIR3
• G3XAD6
• Q0VGE0
• Q499Y4
• Q49AU3
• Q7Z608
• Q8WVN3
• Q96F80
• Q9H077
• hFip1

Gene Name

• FIP1L1

Ensembl ID

• ENST00000306932
• ENSP00000302993
• ENSG00000145216
• ENST00000337488
• ENSP00000336752
• ENST00000358575
• ENSP00000351383
• ENST00000507922
• ENSP00000425456

Symbol

• FIP1
• RHE
• Rhe
• FIP1
• hFip1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
ligand (protein) perturbation	0.96
transcription factor perturbation	0.88
tissue	0.69
virus perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.88   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 140   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.88   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (302)

Explore Interacting Targets

1 – 10 of 302

• See Interactions on String-DB

CPSF4

Tbio

Novelty:  0.00206207

p_int:  0.999943125

p_ni:  0.000056875

Score:  0.999

Data Source:  BioPlex,STRINGDB

P4HA1

Tchem

Family:  Enzyme

Novelty:  0.01624726

p_int:  0.997276207

p_ni:  0.002723793

Score:  0.211

Data Source:  BioPlex,STRINGDB

P4HA2

Tbio

Family:  Enzyme

Novelty:  0.02097718

p_int:  0.99625152

p_ni:  0.003748481

Score:  0.762

Data Source:  BioPlex,STRINGDB

CPSF2

Tbio

Novelty:  0.0510853

p_int:  0.993022404

p_ni:  0.006977597

Score:  0.998

Data Source:  BioPlex,STRINGDB

CPSF4L

Tdark

Novelty:  4.27116708

p_int:  0.926602137

p_ni:  0.073397863

Score:  0.957

Data Source:  BioPlex,STRINGDB

ZC3H18

Tdark

Novelty:  0.3515546

p_int:  0.880800261

p_ni:  0.119199739

Score:  0.318

Data Source:  BioPlex,STRINGDB

WDR33

Tbio

Novelty:  0.09221439

Score:  0.999

Data Source:  STRINGDB

CPSF1

Tbio

Novelty:  0.04396897

Score:  0.999

Data Source:  STRINGDB

CPSF3

Tchem

Novelty:  0.01880576

Score:  0.999

Data Source:  STRINGDB

PCF11

Tbio

Novelty:  0.01882626

Score:  0.998

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (14)

Reactome (13)

KEGG (1)

Gene expression (Transcription) (R-HSA-74160)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	Processing of Capped Intronless Pre-mRNA	28 targets	R-HSA-75067
Reactome	Processing of Intronless Pre-mRNAs	19 targets	R-HSA-77595

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Processing of Capped Intronless Pre-mRNA	28 targets	R-HSA-75067
Processing of Intronless Pre-mRNAs	19 targets	R-HSA-77595

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (1)

Components (2)

Processes (6)

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GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (4)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2	1	2		72.3
neutrophil count	EFO_0004833	1	1	1		50.6
uterine fibroid	EFO_0000731	1	1	0	2.2	36.9
cervical artery dissection	EFO_1000059	1	1	0	1.2	21.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2		72.3
neutrophil count	EFO_0004833	1		50.6
uterine fibroid	EFO_0000731	0	2.2	36.9
cervical artery dissection	EFO_1000059	0	1.2	21.5

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
mRNA processing
Nucleus
Phosphoprotein
Reference proteome
RNA-binding

GWAS Trait Find Similar Targets

No Header	No Header
cervical artery dissection
heel bone mineral density
neutrophil count
uterine fibroid

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	factor interacting with PAPOLA and CPSF1	VGNC:603	107974320
Macaque	platelet derived growth factor receptor alpha [Source:HGNC Symbol;Acc:HGNC:8803]
Mouse	FIP1 like 1 (S. cerevisiae)	MGI:1914149	66899
Rat	factor interacting with PAPOLA and CPSF1	RGD:1309336	289582
Dog	factor interacting with PAPOLA and CPSF1	VGNC:40883	612980

Species	Name	OMA	EggNOG	Inparanoid
Chimp	factor interacting with PAPOLA and CPSF1
Macaque	platelet derived growth factor receptor alpha [Source:HGNC Symbol;Acc:HGNC:8803]
Mouse	FIP1 like 1 (S. cerevisiae)
Rat	factor interacting with PAPOLA and CPSF1
Dog	factor interacting with PAPOLA and CPSF1

Publication Statistics

PubMed Score 203.88

PubMed score by year

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PubTator Score 212.40

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Related Publications

Text Mined References (52)

GeneRif Annotations (30)

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PMID	Year	Title