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Tbio
FIGNL1
Fidgetin-like protein 1

Protein Summary
Description
Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:23754376). May play a role in the control of male meiosis dynamic (By similarity). This gene encodes a member of the AAA ATPase family of proteins. The encoded protein is recruited to sites of DNA damage where it plays a role in DNA double-strand break repair via homologous recombination. This protein has also been shown to localize to the centrosome and inhibit ciliogenesis, and may regulate the proliferation and differentiation of osteoblasts. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356889
  • ENSP00000349356
  • ENSG00000132436
  • ENST00000395556
  • ENSP00000378924
  • ENST00000419119
  • ENSP00000410811
  • ENST00000433017
  • ENSP00000399997
  • ENST00000611938
  • ENSP00000484551
  • ENST00000613602
  • ENSP00000481751
  • ENST00000615084
  • ENSP00000483543
  • ENST00000617389
  • ENSP00000483126
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
transcription factor perturbation
0.91
histone modification site profile
0.89
cellular component
0.84
biological process
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.6   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.6   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (110)
JPT2
Tbio
Novelty:  0.46270217
p_int:  0.999996941
p_ni:  0.000003059
Score:  0.228
Data Source:  BioPlex,STRINGDB
RAD51
Tchem
Novelty:  0.00011516
p_int:  0.999887482
p_ni:  0.000112514
p_wrong:  4e-9
Score:  0.596
Data Source:  BioPlex,STRINGDB
NCAPH2
Tbio
Novelty:  0.12134933
p_int:  0.999615839
p_ni:  0.00038415
p_wrong:  1.1e-8
Data Source:  BioPlex
POTEI
Tdark
Novelty:  0.41311202
p_int:  0.999013261
p_ni:  0.000986739
Score:  0.207
Data Source:  BioPlex,STRINGDB
RHEX
Tbio
Novelty:  0.20957256
p_int:  0.997612005
p_ni:  0.002387311
p_wrong:  6.84e-7
Score:  0.237
Data Source:  BioPlex,STRINGDB
LYZL2
Tdark
Family:  Enzyme
Novelty:  0.50542161
p_int:  0.996701419
p_ni:  0.002991825
p_wrong:  0.000306756
Data Source:  BioPlex
RFXANK
Tbio
Novelty:  0.00355465
p_int:  0.996599446
p_ni:  0.001325541
p_wrong:  0.002075012
Score:  0.199
Data Source:  BioPlex,STRINGDB
TMEM25
Tdark
Novelty:  0.35505784
p_int:  0.996416553
p_ni:  0.000981245
p_wrong:  0.002602202
Data Source:  BioPlex
GFPT2
Tbio
Family:  Enzyme
Novelty:  0.01049877
p_int:  0.996030561
p_ni:  0.003853361
p_wrong:  0.000116078
Score:  0.184
Data Source:  BioPlex,STRINGDB
TNXB
Tbio
Novelty:  0.00517364
p_int:  0.995883473
p_ni:  0.004116502
p_wrong:  2.4e-8
Score:  0.282
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
5
4
6
98.9
monocyte percentage of leukocytes
2
4
5
96.6
4
3
0
1.8
95.1
6
5
0
1.6
94.1
erythrocyte count
3
2
3
92.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
6
98.9
monocyte percentage of leukocytes
5
96.6
0
1.8
95.1
0
1.6
94.1
erythrocyte count
3
92.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
fidgetin like 1
694906
Mouse
MGI:1890648
60530
Rat
RGD:1307112
289777
Dog
fidgetin like 1
VGNC:40880
483232
Horse
fidgetin like 1
VGNC:18042
100052497
Species
Name
OMA
EggNOG
Inparanoid
Macaque
fidgetin like 1
Mouse
Rat
Dog
fidgetin like 1
Horse
fidgetin like 1
Publication Statistics
PubMed Score 10.60
PubMed score by year
PubTator Score 4.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title