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Tbio
FIG4
Polyphosphoinositide phosphatase

Protein Summary
Description
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230124
  • ENSP00000230124
  • ENSG00000112367

Symbol
  • KIAA0274
  • SAC3
  • YVS
  • BTOP
  • SAC3
  • ALS11
  • CMT4J
  • KIAA0274
  • dJ249I4.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
kinase perturbation
0.96
co-expressed gene
0.94
histone modification site profile
0.89
cellular component
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.11   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.11   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
VAC14
Tbio
Novelty:  0.02677738
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PIKFYVE
Tchem
Family:  Kinase
Novelty:  0.00441336
p_int:  0.99999905
p_ni:  9.5e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ANK1
Tbio
Novelty:  0.00225305
p_int:  0.999959465
p_ni:  0.000040524
p_wrong:  1.1e-8
Score:  0.842
Data Source:  BioPlex,STRINGDB
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.999890706
p_ni:  0.000109294
Score:  0.185
Data Source:  BioPlex,STRINGDB
SBF2
Tbio
Novelty:  0.02647873
Score:  0.846
Data Source:  STRINGDB
MTMR2
Tbio
Family:  Enzyme
Novelty:  0.01403122
Score:  0.775
Data Source:  STRINGDB
NAAA
Tchem
Family:  Enzyme
Novelty:  0.00368876
Score:  0.756
Data Source:  STRINGDB
LAMP2
Tbio
Novelty:  0.00168009
Score:  0.717
Data Source:  STRINGDB
WIPI1
Tbio
Novelty:  0.01070744
Score:  0.703
Data Source:  STRINGDB
PIK3C3
Tchem
Family:  Kinase
Novelty:  0.00269825
Score:  0.693
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the Golgi membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the Golgi membrane
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
2
2
81.8
red blood cell distribution width
1
1
1
64.4
appendicular lean mass
1
2
2
50.5
BMI-adjusted hip circumference
1
1
1
28.1
apolipoprotein B measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
81.8
red blood cell distribution width
1
64.4
appendicular lean mass
2
50.5
BMI-adjusted hip circumference
1
28.1
apolipoprotein B measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FIG4 phosphoinositide 5-phosphatase
VGNC:2832
462932
Macaque
FIG4 phosphoinositide 5-phosphatase
699914
Mouse
MGI:2143585
103199
Rat
RGD:1311375
309855
Dog
FIG4 phosphoinositide 5-phosphatase
VGNC:40879
475023
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FIG4 phosphoinositide 5-phosphatase
Macaque
FIG4 phosphoinositide 5-phosphatase
Mouse
Rat
Dog
FIG4 phosphoinositide 5-phosphatase
Publication Statistics
PubMed Score 130.11
PubMed score by year
PubTator Score 37.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title