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Tbio
FHL5
Four and a half LIM domains protein 5

Protein Summary
Description
May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner. The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326771
  • ENSP00000326022
  • ENSG00000112214
  • ENST00000541107
  • ENSP00000442357

Symbol
  • ACT
  • ACT
  • FHL-5
  • dJ393D12.2
  • 1700027G07Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.63
kinase perturbation
0.6
protein complex
0.57
gene perturbation
0.55
phenotype
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.08   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.08   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
CEP76
Tdark
Novelty:  0.3880387
p_int:  0.999963572
p_ni:  0.000036365
p_wrong:  6.3e-8
Score:  0.21
Data Source:  BioPlex,STRINGDB
TAX1BP1
Tbio
Novelty:  0.02498501
p_int:  0.999927893
p_ni:  0.000072107
Data Source:  BioPlex
ZNF131
Tbio
Family:  TF
Novelty:  0.18894578
p_int:  0.999881524
p_ni:  0.000068394
p_wrong:  0.000050083
Score:  0.799
Data Source:  BioPlex,STRINGDB
ZMYM1
Tdark
Novelty:  0.3860445
p_int:  0.999794476
p_ni:  0.000205519
p_wrong:  5e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
SCNM1
Tbio
Novelty:  0.19700548
p_int:  0.99936427
p_ni:  0.000635011
p_wrong:  7.19e-7
Data Source:  BioPlex
ZMYM6
Tdark
Novelty:  0.4933879
p_int:  0.987083939
p_ni:  0.01291606
Data Source:  BioPlex
PDLIM7
Tbio
Novelty:  0.00544518
p_int:  0.946659386
p_ni:  0.053340573
p_wrong:  4.1e-8
Score:  0.235
Data Source:  BioPlex,STRINGDB
CTU1
Tbio
Novelty:  0.04670058
p_int:  0.840714837
p_ni:  0.159270305
p_wrong:  0.000014858
Data Source:  BioPlex
CREM
Tbio
Family:  TF
Novelty:  0.00331358
Score:  0.97
Data Source:  STRINGDB
KIF17
Tbio
Novelty:  0.00830285
Score:  0.968
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
91.9
Headache
1
1
1
80.2
2
2
0
1.2
67.5
1
1
0
1.1
37.6
systolic blood pressure
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
91.9
Headache
1
80.2
0
1.2
67.5
0
1.1
37.6
systolic blood pressure
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
four and a half LIM domains 5
VGNC:2831
472076
Macaque
four and a half LIM domains 5
704568
Mouse
MGI:1913192
57756
Rat
RGD:1307056
297954
Dog
four and a half LIM domains 5
VGNC:40874
475000
Species
Name
OMA
EggNOG
Inparanoid
Chimp
four and a half LIM domains 5
Macaque
four and a half LIM domains 5
Mouse
Rat
Dog
four and a half LIM domains 5
Publication Statistics
PubMed Score 2.08
PubMed score by year
PubTator Score 10.28
PubTator score by year
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Related Publications
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PMID
Year
Title