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Tbio
FHL3
Four and a half LIM domains protein 3

Protein Summary
Description
The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373016
  • ENSP00000362107
  • ENSG00000183386

Symbol
  • SLIM2
  • SLIM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.74
cellular component
0.65
cell type or tissue
0.57
tissue sample
0.52
transcription factor binding site profile
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.45   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.45   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
MRTFB
Tbio
Novelty:  0.02702072
p_int:  0.999999985
p_ni:  2e-9
p_wrong:  1.3e-8
Score:  0.222
Data Source:  BioPlex,STRINGDB
KCTD3
Tdark
Novelty:  0.33599775
p_int:  0.999999838
p_ni:  1.62e-7
Data Source:  BioPlex
TJAP1
Tbio
Novelty:  0.008967
p_int:  0.999999796
p_ni:  2.02e-7
p_wrong:  2e-9
Score:  0.205
Data Source:  BioPlex,STRINGDB
ZNF512B
Tbio
Family:  TF
Novelty:  0.0976969
p_int:  0.999999775
p_ni:  2.25e-7
Score:  0.208
Data Source:  BioPlex,STRINGDB
COBL
Tbio
Novelty:  0.01903038
p_int:  0.999999494
p_ni:  5.06e-7
Data Source:  BioPlex
FAM122B
Tdark
Novelty:  1.90668674
p_int:  0.999998456
p_ni:  0.000001544
Score:  0.337
Data Source:  BioPlex,STRINGDB
SHKBP1
Tbio
Novelty:  0.00235279
p_int:  0.999987881
p_ni:  0.000012119
Score:  0.204
Data Source:  BioPlex,STRINGDB
QSER1
Tdark
Novelty:  0.62017582
p_int:  0.999951601
p_ni:  0.000048399
Score:  0.157
Data Source:  BioPlex,STRINGDB
HIPK1
Tchem
Family:  Kinase
Novelty:  0.11377215
p_int:  0.999948509
p_ni:  5.41e-7
p_wrong:  0.000050951
Score:  0.354
Data Source:  BioPlex,STRINGDB
ZBTB21
Tbio
Family:  TF
Novelty:  0.16032292
p_int:  0.999907507
p_ni:  0.000092493
Score:  0.168
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
2
2
3
90.8
4
2
4
76.3
2
2
0
1.1
63.1
body height
1
1
1
57.8
heel bone mineral density
3
1
3
56.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
3
90.8
4
76.3
0
1.1
63.1
body height
1
57.8
heel bone mineral density
3
56.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
four and a half LIM domains 3
VGNC:540
456768
Macaque
four and a half LIM domains 3
715313
Mouse
MGI:1341092
14201
Rat
RGD:1307180
313582
Dog
four and a half LIM domains 3
VGNC:40873
608080
Species
Name
OMA
EggNOG
Inparanoid
Chimp
four and a half LIM domains 3
Macaque
four and a half LIM domains 3
Mouse
Rat
Dog
four and a half LIM domains 3
Publication Statistics
PubMed Score 11.45
PubMed score by year
PubTator Score 29.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title