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Tbio
FHL1
Four and a half LIM domains protein 1

Protein Summary
Description
May have an involvement in muscle development or hypertrophy. This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345434
  • ENSP00000071281
  • ENSG00000022267
  • ENST00000370683
  • ENSP00000359717
  • ENST00000370690
  • ENSP00000359724
  • ENST00000394153
  • ENSP00000377709
  • ENST00000394155
  • ENSP00000377710
  • ENST00000535737
  • ENSP00000444815
  • ENST00000539015
  • ENSP00000437673
  • ENST00000543669
  • ENSP00000443333
  • ENST00000618438
  • ENSP00000477609
  • ENST00000628568
  • ENSP00000486782
  • ENST00000629039
  • ENSP00000486439
  • ENST00000630084
  • ENSP00000485897

Symbol
  • SLIM1
  • KYOT
  • SLIM
  • FCMSU
  • FHL-1
  • FHL1A
  • FHL1B
  • FLH1A
  • SLIM1
  • XMPMA
  • RBMX1A
  • RBMX1B
  • SLIM-1
  • SLIMMER
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.99
transcription factor perturbation
0.97
PubMedID
0.92
kinase perturbation
0.91
hub protein
0.9


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.99   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 439   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.99   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 439   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
RBPJ
Tchem
Family:  TF
Novelty:  0.00168834
Score:  0.949
Data Source:  STRINGDB
TTN
Tbio
Family:  Kinase
Novelty:  0.00040356
Score:  0.774
Data Source:  STRINGDB
INPP5A
Tchem
Family:  Enzyme
Novelty:  0.03249263
Score:  0.752
Data Source:  STRINGDB
MDC1
Tbio
Novelty:  0.00533097
Score:  0.7
Data Source:  STRINGDB
AMIGO1
Tbio
Novelty:  0.00864791
Score:  0.657
Data Source:  STRINGDB
NRIP1
Tbio
Novelty:  0.00551568
Score:  0.639
Data Source:  STRINGDB
PLEKHG2
Tbio
Novelty:  0.19545538
Score:  0.636
Data Source:  STRINGDB
STAT5B
Tchem
Family:  TF
Novelty:  0.00074178
Score:  0.603
Data Source:  STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.603
Data Source:  STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.601
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
1
1
37.7
pulse pressure measurement
1
1
1
32.3
systolic blood pressure
1
1
1
22.8
angina pectoris
1
1
1
21.6
educational attainment
1
1
1
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
37.7
pulse pressure measurement
1
32.3
systolic blood pressure
1
22.8
angina pectoris
1
21.6
educational attainment
1
6.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
four and a half LIM domains 1
710692
Mouse
MGI:1298387
14199
Rat
RGD:2615
25177
Dog
four and a half LIM domains 1
VGNC:40871
492162
Cow
four and a half LIM domains 1
VGNC:28999
509056
Species
Name
OMA
EggNOG
Inparanoid
Macaque
four and a half LIM domains 1
Mouse
Rat
Dog
four and a half LIM domains 1
Cow
four and a half LIM domains 1
Publication Statistics
PubMed Score 87.99
PubMed score by year
PubTator Score 146.37
PubTator score by year
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Related Publications
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PMID
Year
Title