Tbio FGL2 Fibroleukin

Protein Summary

Description

May play a role in physiologic lymphocyte functions at mucosal sites. The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q14314

Gene Name

• FGL2

Ensembl ID

• ENST00000248598
• ENSP00000248598
• ENSG00000127951

Symbol

• T49
• pT49

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.95
gene perturbation	0.89
co-expressed gene	0.61
protein domain	0.58
microRNA	0.56

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Fibroleukin

DTO Classes

Protein / Signaling / Fibroleukin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.19   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 362   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.19   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0