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Tbio
FGL1
Fibrinogen-like protein 1

Protein Summary
Description
Has hepatocyte mitogenic activity. Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381840
  • ENSP00000371262
  • ENSG00000104760
  • ENST00000381841
  • ENSP00000371263
  • ENST00000398054
  • ENSP00000381131
  • ENST00000398056
  • ENSP00000381133
  • ENST00000427924
  • ENSP00000401952
  • ENST00000518650
  • ENSP00000428430
  • ENST00000522444
  • ENSP00000429757

Symbol
  • HFREP1
  • HFREP1
  • HP-041
  • LFIRE1
  • LFIRE-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
protein domain
0.58
cell type or tissue
0.57
disease
0.57
small molecule perturbation
0.56


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.56   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 355   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.56   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 355   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0