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Tbio
FGL1
Fibrinogen-like protein 1

Protein Summary
Description
Has hepatocyte mitogenic activity. Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381840
  • ENSP00000371262
  • ENSG00000104760
  • ENST00000381841
  • ENSP00000371263
  • ENST00000398054
  • ENSP00000381131
  • ENST00000398056
  • ENSP00000381133
  • ENST00000427924
  • ENSP00000401952
  • ENST00000518650
  • ENSP00000428430
  • ENST00000522444
  • ENSP00000429757

Symbol
  • HFREP1
  • HFREP1
  • HP-041
  • LFIRE1
  • LFIRE-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
protein domain
0.58
cell type or tissue
0.57
disease
0.57
small molecule perturbation
0.56


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.39   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 355   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.39   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 355   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (113)
TBC1D10A
Tbio
Novelty:  0.16930827
p_int:  1
Score:  0.187
Data Source:  BioPlex,STRINGDB
PPIL2
Tbio
Family:  Enzyme
Novelty:  0.04860473
p_int:  0.999999646
p_ni:  3.54e-7
Data Source:  BioPlex
ARHGEF2
Tbio
Novelty:  0.01494954
p_int:  0.99999947
p_ni:  5.29e-7
p_wrong:  1e-9
Data Source:  BioPlex
C1orf198
Tdark
Novelty:  3.89427313
p_int:  0.999998618
p_ni:  0.000001381
p_wrong:  2e-9
Data Source:  BioPlex
FBXO38
Tbio
Novelty:  0.06588101
p_int:  0.999998061
p_ni:  0.000001939
Score:  0.187
Data Source:  BioPlex,STRINGDB
FAM172A
Tbio
Novelty:  0.1200899
p_int:  0.999997543
p_ni:  0.000002456
Score:  0.187
Data Source:  BioPlex,STRINGDB
TEDC2
Tdark
Novelty:  1.16645057
p_int:  0.999997364
p_ni:  0.000002019
p_wrong:  6.17e-7
Score:  0.392
Data Source:  BioPlex,STRINGDB
TUBE1
Tbio
Novelty:  0.03897856
p_int:  0.999995917
p_ni:  0.000004068
p_wrong:  1.5e-8
Score:  0.532
Data Source:  BioPlex,STRINGDB
ALDH5A1
Tclin
Family:  Enzyme
Novelty:  0.00461791
p_int:  0.999994714
p_ni:  0.000005286
Score:  0.252
Data Source:  BioPlex,STRINGDB
LCMT2
Tbio
Family:  Enzyme
Novelty:  0.0388779
p_int:  0.999992287
p_ni:  0.000007713
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
31.4
mean corpuscular volume
1
1
1
30.2
self reported educational attainment
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
31.4
mean corpuscular volume
1
30.2
self reported educational attainment
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:102795
234199
Rat
RGD:620169
246186
Dog
fibrinogen like 1
VGNC:40864
475617
Horse
fibrinogen like 1
VGNC:18030
100054096
Cow
fibrinogen like 1
VGNC:28992
508090
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
fibrinogen like 1
Horse
fibrinogen like 1
Cow
fibrinogen like 1
Publication Statistics
PubMed Score 49.39
PubMed score by year
PubTator Score 14.66
PubTator score by year
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Related Publications
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PMID
Year
Title