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Tbio
FGGY
FGGY carbohydrate kinase domain-containing protein

Protein Summary
Description
This gene encodes a protein that phosphorylates carbohydrates such as ribulose, ribitol, and L-arabinitol. Genome-wide association studies in some populations have found an association between polymorphisms in this gene and sporadic amyotrophic lateral sclerosis, but studies of other populations have not been able to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303721
  • ENSP00000305922
  • ENSG00000172456
  • ENST00000371210
  • ENSP00000360254
  • ENST00000371212
  • ENSP00000360256
  • ENST00000371218
  • ENSP00000360262
  • ENST00000635156
  • ENSP00000489417
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
histone modification site profile
0.86
transcription factor binding site profile
0.77
phenotype
0.63
transcription factor
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.43   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.43   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
NSFL1C
Tbio
Novelty:  0.05494848
p_int:  0.999999996
p_wrong:  4e-9
Score:  0.504
Data Source:  BioPlex,STRINGDB
EAF1
Tbio
Novelty:  0.81120425
p_int:  0.999550396
p_ni:  0.000056315
p_wrong:  0.000393289
Score:  0.208
Data Source:  BioPlex,STRINGDB
SHPK
Tbio
Family:  Kinase
Novelty:  0.16166855
Score:  0.759
Data Source:  STRINGDB
CTNS
Tbio
Novelty:  0.00448623
Score:  0.718
Data Source:  STRINGDB
RBM33
Tdark
Novelty:  0.1482404
Score:  0.699
Data Source:  STRINGDB
ITPR2
Tbio
Family:  IC
Novelty:  0.00619813
Score:  0.694
Data Source:  STRINGDB
DPP6
Tbio
Family:  Enzyme
Novelty:  0.00435138
Score:  0.678
Data Source:  STRINGDB
XYLB
Tbio
Family:  Kinase
Novelty:  0.00540687
Score:  0.673
Data Source:  STRINGDB
USP24
Tbio
Family:  Enzyme
Novelty:  0.07281326
Score:  0.658
Data Source:  STRINGDB
MYSM1
Tbio
Family:  TF
Novelty:  0.03983046
Score:  0.653
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
63.4
monocyte count
1
1
1
57.3
platelet crit
1
1
1
44.2
aspartate aminotransferase measurement
1
1
0
6.3
42.3
aortic root size
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
63.4
monocyte count
1
57.3
platelet crit
1
44.2
aspartate aminotransferase measurement
0
6.3
42.3
aortic root size
1
31.4
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FGGY carbohydrate kinase domain containing
VGNC:11434
456894
Macaque
FGGY carbohydrate kinase domain containing
693720
Mouse
MGI:1922828
75578
Rat
RGD:1359429
298250
Dog
FGGY carbohydrate kinase domain containing
VGNC:40863
479554
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FGGY carbohydrate kinase domain containing
Macaque
FGGY carbohydrate kinase domain containing
Mouse
Rat
Dog
FGGY carbohydrate kinase domain containing
Publication Statistics
PubMed Score 20.43
PubMed score by year
PubTator Score 4.61
PubTator score by year
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Related Publications
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PMID
Year
Title