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Tbio
FGFRL1
Fibroblast growth factor receptor-like 1

Protein Summary
Description
Has a negative effect on cell proliferation. The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264748
  • ENSP00000264748
  • ENSG00000127418
  • ENST00000398484
  • ENSP00000381498
  • ENST00000504138
  • ENSP00000423091
  • ENST00000510644
  • ENSP00000425025

Symbol
  • FGFR5
  • FHFR
  • FHFR
  • FGFR5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
phenotype
0.73
protein domain
0.73
transcription factor perturbation
0.68
small molecule perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.48   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 286   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.48   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0