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Tbio
FGFRL1
Fibroblast growth factor receptor-like 1

Protein Summary
Description
Has a negative effect on cell proliferation. The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264748
  • ENSP00000264748
  • ENSG00000127418
  • ENST00000398484
  • ENSP00000381498
  • ENST00000504138
  • ENSP00000423091
  • ENST00000510644
  • ENSP00000425025

Symbol
  • FGFR5
  • FHFR
  • FHFR
  • FGFR5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
phenotype
0.73
protein domain
0.73
transcription factor perturbation
0.68
small molecule perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.94   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 286   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.94   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
CLEC4A
Tbio
Novelty:  0.01821643
p_int:  0.999997232
p_ni:  0.000002694
p_wrong:  7.3e-8
Data Source:  BioPlex
KLRG2
Tdark
Novelty:  1.19446694
p_int:  0.999997129
p_ni:  0.000002831
p_wrong:  4e-8
Score:  0.201
Data Source:  BioPlex,STRINGDB
TRIM44
Tbio
Novelty:  0.00483553
p_int:  0.999969859
p_ni:  0.000019197
p_wrong:  0.000010944
Data Source:  BioPlex
UBE2O
Tbio
Novelty:  0.07084123
p_int:  0.999936193
p_ni:  0.000063807
Data Source:  BioPlex
CD44
Tbio
Novelty:  0.00011321
p_int:  0.999600094
p_ni:  0.000338299
p_wrong:  0.000061607
Score:  0.156
Data Source:  BioPlex,STRINGDB
BACH1
Tbio
Family:  TF
Novelty:  0.04011328
p_int:  0.999301047
p_ni:  0.000698927
p_wrong:  2.6e-8
Data Source:  BioPlex
TERF2
Tchem
Family:  TF
Novelty:  0.01003649
p_int:  0.998520664
p_ni:  0.001478231
p_wrong:  0.000001105
Data Source:  BioPlex
TMED2
Tbio
Novelty:  0.03731104
p_int:  0.998122648
p_ni:  0.00184115
p_wrong:  0.000036202
Data Source:  BioPlex
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.997487038
p_ni:  0.002408679
p_wrong:  0.000104283
Score:  0.2
Data Source:  BioPlex,STRINGDB
DCAF1
Tbio
Novelty:  0.0170232
p_int:  0.994806249
p_ni:  0.005193748
p_wrong:  3e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
FGFRL1 modulation of FGFR1 signaling (R-HSA-5658623)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FGFRL1 modulation of FGFR1 signaling
Reactome
Signal Transduction
Reactome
Signaling by FGFR
Reactome
Signaling by FGFR1
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
FGFRL1 modulation of FGFR1 signaling
Signal Transduction
Signaling by FGFR
Signaling by FGFR1
Signaling by Receptor Tyrosine Kinases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
14
22
99.8
8
5
2
1.2
97.5
waist-hip ratio
3
8
8
91
bone density
4
5
5
90.5
BMI-adjusted waist-hip ratio
3
7
8
90.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
22
99.8
2
1.2
97.5
waist-hip ratio
8
91
bone density
5
90.5
BMI-adjusted waist-hip ratio
8
90.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
fibroblast growth factor receptor like 1
702927
Mouse
MGI:2150920
116701
Rat
RGD:735156
360903
Dog
fibroblast growth factor receptor like 1
VGNC:40862
102151155
Horse
fibroblast growth factor receptor like 1
VGNC:51188
100630904
Species
Name
OMA
EggNOG
Inparanoid
Macaque
fibroblast growth factor receptor like 1
Mouse
Rat
Dog
fibroblast growth factor receptor like 1
Horse
fibroblast growth factor receptor like 1
Publication Statistics
PubMed Score 56.94
PubMed score by year
PubTator Score 28.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title