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Tclin
FGFR4
Fibroblast growth factor receptor 4

Protein Summary
Description
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292408
  • ENSP00000292408
  • ENSG00000160867
  • ENST00000393637
  • ENSP00000377254
  • ENST00000502906
  • ENSP00000424960

Symbol
  • JTK2
  • TKF
  • TKF
  • JTK2
  • CD334
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
biological process
0.95
PubMedID
0.9
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 399.45   (req: < 5)
Gene RIFs: 141   (req: <= 3)
Antibodies: 736   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 399.45   (req: >= 5)
Gene RIFs: 141   (req: > 3)
Antibodies: 736   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 527
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (173)
CLEC4A
Tbio
Novelty:  0.01821643
p_int:  0.999998184
p_ni:  0.000001816
Data Source:  BioPlex
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.999983486
p_ni:  0.000016508
p_wrong:  6e-9
Score:  0.16
Data Source:  BioPlex,STRINGDB
TMX1
Tbio
Novelty:  0.03444237
p_int:  0.999979789
p_ni:  0.000020033
p_wrong:  1.78e-7
Score:  0.223
Data Source:  BioPlex,STRINGDB
LRRIQ1
Tdark
Novelty:  1.8251367
p_int:  0.999976021
p_ni:  0.000017851
p_wrong:  0.000006128
Score:  0.183
Data Source:  BioPlex,STRINGDB
MRAP2
Tbio
Novelty:  0.0420503
p_int:  0.99996634
p_ni:  0.000028737
p_wrong:  0.000004924
Data Source:  BioPlex
TNFRSF10A
Tchem
Novelty:  0.0003383
p_int:  0.999959782
p_ni:  0.000035298
p_wrong:  0.00000492
Data Source:  BioPlex
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.999937085
p_ni:  0.00006291
p_wrong:  5e-9
Score:  0.219
Data Source:  BioPlex,STRINGDB
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
p_int:  0.991399246
p_ni:  0.001688936
p_wrong:  0.006911818
Score:  0.196
Data Source:  BioPlex,STRINGDB
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.985179999
p_ni:  0.010930346
p_wrong:  0.003889655
Data Source:  BioPlex
FGF1
Tchem
Novelty:  0.00055979
Score:  0.993
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (110)
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

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Find Similar Targets
Items per page:
1 – 5 of 38
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downstream signaling of activated FGFR4
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Downstream signaling of activated FGFR4
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (41)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
7
11
30
96.9
waist-hip ratio
3
8
11
95.8
BMI-adjusted waist-hip ratio
11
7
17
95.8
body height
3
4
5
89.4
waist circumference
2
4
7
78.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
30
96.9
waist-hip ratio
11
95.8
BMI-adjusted waist-hip ratio
17
95.8
body height
5
89.4
waist circumference
7
78.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor receptor 4
VGNC:4004
462301
Macaque
fibroblast growth factor receptor 4
698494
Mouse
MGI:95525
14186
Rat
RGD:2612
25114
Dog
fibroblast growth factor receptor 4
VGNC:40861
489095
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor receptor 4
Macaque
fibroblast growth factor receptor 4
Mouse
Rat
Dog
fibroblast growth factor receptor 4
Publication Statistics
PubMed Score 399.45
PubMed score by year
PubTator Score 285.40
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title