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Tclin
FGFR2
Fibroblast growth factor receptor 2

Protein Summary
Description
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346997
  • ENSP00000263451
  • ENSG00000066468
  • ENST00000356226
  • ENSP00000348559
  • ENST00000357555
  • ENSP00000350166
  • ENST00000358487
  • ENSP00000351276
  • ENST00000359354
  • ENSP00000352309
  • ENST00000360144
  • ENSP00000353262
  • ENST00000369056
  • ENSP00000358052
  • ENST00000369058
  • ENSP00000358054
  • ENST00000369060
  • ENSP00000358056
  • ENST00000369061
  • ENSP00000358057
  • ENST00000457416
  • ENSP00000410294

Symbol
  • BEK
  • KGFR
  • KSAM
  • BEK
  • JWS
  • BBDS
  • CEK3
  • CFD1
  • ECT1
  • KGFR
  • TK14
  • TK25
  • BFR-1
  • CD332
  • K-SAM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
PubMedID
1
phenotype
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1632.64   (req: < 5)
Gene RIFs: 419   (req: <= 3)
Antibodies: 1176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1632.64   (req: >= 5)
Gene RIFs: 419   (req: > 3)
Antibodies: 1176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 118
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 697
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (310)
FGFR3
Tclin
Family:  Kinase
Novelty:  0.00071612
p_int:  1
Score:  0.965
Data Source:  BioPlex,STRINGDB
FGFR1
Tclin
Family:  Kinase
Novelty:  0.00055714
p_int:  0.999999818
p_ni:  1.78e-7
p_wrong:  4e-9
Score:  0.385
Data Source:  BioPlex,STRINGDB
FGF2
Tchem
Novelty:  0.00007856
p_int:  0.999999577
p_ni:  4.23e-7
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
SNX24
Tdark
Novelty:  0.20838126
p_int:  0.999999179
p_ni:  8.21e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
GAPVD1
Tbio
Family:  Enzyme
Novelty:  0.13142098
p_int:  0.999998428
p_ni:  0.000001572
Score:  0.173
Data Source:  BioPlex,STRINGDB
C8orf74
Tdark
Novelty:  3.88335704
p_int:  0.999998346
p_ni:  0.000001653
p_wrong:  1e-9
Score:  0.455
Data Source:  BioPlex,STRINGDB
SNX22
Tdark
Novelty:  0.26806147
p_int:  0.999996333
p_ni:  0.000003636
p_wrong:  3.1e-8
Score:  0.734
Data Source:  BioPlex,STRINGDB
UBE4A
Tbio
Novelty:  0.02576018
p_int:  0.99999342
p_ni:  0.000006577
p_wrong:  3e-9
Score:  0.305
Data Source:  BioPlex,STRINGDB
IP6K1
Tbio
Family:  Kinase
Novelty:  0.03418032
p_int:  0.999993228
p_ni:  0.000006772
Score:  0.23
Data Source:  BioPlex,STRINGDB
RPS6KA3
Tchem
Family:  Kinase
Novelty:  0.00221219
p_int:  0.999984207
p_ni:  0.000015792
Score:  0.239
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (84)
Activated point mutants of FGFR2 (R-HSA-2033519)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 43
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated point mutants of FGFR2
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (133)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
16
9
0
1.3
99.5
serum gamma-glutamyl transferase measurement
2
2
2
80.3
prostate specific antigen measurement
1
2
2
77.9
estrogen receptor status
2
2
0
1.6
64.2
1
1
0
1.2
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
99.5
serum gamma-glutamyl transferase measurement
2
80.3
prostate specific antigen measurement
2
77.9
estrogen receptor status
0
1.6
64.2
0
1.2
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor receptor 2
VGNC:51977
466220
Macaque
fibroblast growth factor receptor 2
715949
Mouse
MGI:95523
14183
Rat
RGD:2611
25022
Dog
fibroblast growth factor receptor 2
VGNC:40859
415125
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor receptor 2
Macaque
fibroblast growth factor receptor 2
Mouse
Rat
Dog
fibroblast growth factor receptor 2
Publication Statistics
PubMed Score 1632.64
PubMed score by year
PubTator Score 1067.77
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title