Tbio FGFBP3 Fibroblast growth factor-binding protein 3

Protein Summary

Description

Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability.

Uniprot Accession IDs

• Q8TAT2
• B2RD68
• Q8NBN0
• FGF-BP3

Gene Name

• FGFBP3

Ensembl ID

• ENST00000311575
• ENSP00000339067
• ENSG00000174721

Symbol

• C10orf13
• FGF-BP3
• C10orf13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.77
transcription factor	0.56
histone modification site profile	0.48
tissue	0.47
microRNA	0.45

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.17   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 69   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.17   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0