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Tbio
FGF20
Fibroblast growth factor 20

Protein Summary
Description
Neurotrophic factor that regulates central nervous development and function. The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000180166
  • ENSP00000180166
  • ENSG00000078579

Symbol
  • RHDA2
  • FGF-20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.73
PubMedID
0.66
biological process
0.63
pathway
0.61
interacting protein
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.9   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.9   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
FGF9
Tbio
Novelty:  0.003428
p_int:  0.779251152
p_wrong:  0.220748848
Score:  0.961
Data Source:  BioPlex,STRINGDB
FGFR1
Tclin
Family:  Kinase
Novelty:  0.00055714
Score:  0.993
Data Source:  STRINGDB
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
Score:  0.983
Data Source:  STRINGDB
FGFR4
Tclin
Family:  Kinase
Novelty:  0.00258329
Score:  0.982
Data Source:  STRINGDB
FGFR3
Tclin
Family:  Kinase
Novelty:  0.00071612
Score:  0.978
Data Source:  STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.939
Data Source:  STRINGDB
FGF19
Tbio
Novelty:  0.00317427
Score:  0.934
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.932
Data Source:  STRINGDB
FRS2
Tbio
Novelty:  0.00654052
Score:  0.928
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.924
Data Source:  STRINGDB
Nearest Tclin Targets (18)
Explore Nearest Tclin Targets
Pathways (96)
Activated point mutants of FGFR2 (R-HSA-2033519)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 73
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated point mutants of FGFR2
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triacylglycerol 52:2 measurement
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triacylglycerol 52:2 measurement
1
0.1
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1891346
80857
Rat
RGD:71068
66017
Dog
fibroblast growth factor 20
VGNC:51802
100855820
Horse
fibroblast growth factor 20
VGNC:18015
100050037
Cow
fibroblast growth factor 20
VGNC:28976
539083
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
fibroblast growth factor 20
Horse
fibroblast growth factor 20
Cow
fibroblast growth factor 20
Publication Statistics
PubMed Score 87.90
PubMed score by year
PubTator Score 46.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title