Tbio FGF12 Fibroblast growth factor 12

Protein Summary

Description

Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P61328
• B2R6B7
• B2R976
• O35339
• P70376
• Q8TBG5
• Q92912
• Q93001
• FGF-12

Gene Name

• FGF12

Ensembl ID

• ENST00000445105
• ENSP00000393686
• ENSG00000114279
• ENST00000450716
• ENSP00000397635
• ENST00000454309
• ENSP00000413496

Symbol

• FGF12B
• FHF1
• FHF1
• EIEE47
• FGF12B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.99
microRNA	0.86
virus perturbation	0.79
disease	0.72
phenotype	0.71

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Fibroblast Growth Factor 12

DTO Classes

Protein / Signaling / Growth Factor / Fibroblast Growth Factor 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.45   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 212   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.45   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (149)

Explore Interacting Targets

1 – 10 of 149

• See Interactions on String-DB

RTF1

Tbio

Family:  Enzyme

Novelty:  0.02255644

p_int:  0.999999933

p_ni:  6.1e-8

p_wrong:  5e-9

Data Source:  BioPlex

MAPK8IP2

Tbio

Family:  Enzyme

Novelty:  0.01788453

p_int:  0.999999151

p_ni:  8.49e-7

Score:  0.657

Data Source:  BioPlex,STRINGDB

FNBP4

Tdark

Novelty:  0.17447776

p_int:  0.999996759

p_ni:  0.000003241

Data Source:  BioPlex

SCN5A

Tclin

Family:  IC

Novelty:  0.00050944

p_int:  0.999987629

p_ni:  0.00000231

p_wrong:  0.000010061

Score:  0.918

Data Source:  BioPlex,STRINGDB

CTDP1

Tbio

Family:  Enzyme

Novelty:  0.01121863

p_int:  0.999986443

p_ni:  0.000001509

p_wrong:  0.000012048

Data Source:  BioPlex

AFF4

Tbio

Family:  TF

Novelty:  0.02113896

p_int:  0.99996644

p_ni:  0.00003356

Data Source:  BioPlex

DCAF16

Tdark

Novelty:  0.35666992

p_int:  0.999913226

p_ni:  0.000086362

p_wrong:  4.12e-7

Data Source:  BioPlex

WDR75

Tbio

Novelty:  0.09443914

p_int:  0.999910437

p_ni:  0.000089563

Data Source:  BioPlex

GPBP1L1

Tdark

Novelty:  0.69320833

p_int:  0.999882453

p_ni:  0.000110088

p_wrong:  0.000007459

Data Source:  BioPlex

CHD9

Tbio

Family:  Epigenetic

Novelty:  0.06234268

p_int:  0.99909962

p_ni:  0.000900351

p_wrong:  2.9e-8

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (9)

Reactome (3)

PathwayCommons (1)

WikiPathways (5)

Cardiac conduction (R-HSA-5576891)

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cardiac conduction	137 targets	R-HSA-5576891
Reactome	Muscle contraction	202 targets	R-HSA-397014
Reactome	Phase 0 - rapid depolarisation	44 targets	R-HSA-5576892

Name	Explore in Pharos	Explore in Source
Cardiac conduction	137 targets	R-HSA-5576891
Muscle contraction	202 targets	R-HSA-397014
Phase 0 - rapid depolarisation	44 targets	R-HSA-5576892

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (23)

Functions (4)

Components (2)

Processes (17)

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1 – 4 of 4

GO Term	Evidence	Assigned by
heparin binding	Inferred from Direct Assay (IDA)	MGI
ion channel binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
sodium channel regulator activity	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
growth factor activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations (null)

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	1	1	1		17.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	1		17.8

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UniProt Keyword Find Similar Targets

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3D-structure
Alternative splicing
Complete proteome
Disease mutation
Epilepsy
Growth factor
Nucleus
Reference proteome

GWAS Trait Find Similar Targets

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mathematical ability

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	fibroblast growth factor 12		705813
Mouse	fibroblast growth factor 12	MGI:109183	14167
Rat	fibroblast growth factor 12	RGD:620163	170630
Dog	fibroblast growth factor 12	VGNC:40841	478676
Horse	fibroblast growth factor 12	VGNC:18011	100059907

Species	Name	OMA	EggNOG	Inparanoid
Macaque	fibroblast growth factor 12
Mouse	fibroblast growth factor 12
Rat	fibroblast growth factor 12
Dog	fibroblast growth factor 12
Horse	fibroblast growth factor 12

Publication Statistics

PubMed Score 55.45

PubMed score by year

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PubTator Score 27.64

PubTator score by year

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Related Publications

Text Mined References (34)

GeneRif Annotations (19)

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PMID	Year	Title