Tbio FGF12 Fibroblast growth factor 12

Protein Summary

Description

Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P61328
• B2R6B7
• B2R976
• O35339
• P70376
• Q8TBG5
• Q92912
• Q93001
• FGF-12

Gene Name

• FGF12

Ensembl ID

• ENST00000445105
• ENSP00000393686
• ENSG00000114279
• ENST00000450716
• ENSP00000397635
• ENST00000454309
• ENSP00000413496

Symbol

• FGF12B
• FHF1
• FHF1
• EIEE47
• FGF12B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.99
microRNA	0.86
virus perturbation	0.79
disease	0.72
phenotype	0.71

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Fibroblast Growth Factor 12

DTO Classes

Protein / Signaling / Growth Factor / Fibroblast Growth Factor 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.89   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 212   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.89   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0