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Tbio
FGF12
Fibroblast growth factor 12

Protein Summary
Description
Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants enco ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000445105
  • ENSP00000393686
  • ENSG00000114279
  • ENST00000450716
  • ENSP00000397635
  • ENST00000454309
  • ENSP00000413496

Symbol
  • FGF12B
  • FHF1
  • FHF1
  • EIEE47
  • FGF12B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
microRNA
0.86
virus perturbation
0.79
disease
0.72
phenotype
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.45   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.45   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (149)
RTF1
Tbio
Family:  Enzyme
Novelty:  0.02255644
p_int:  0.999999933
p_ni:  6.1e-8
p_wrong:  5e-9
Data Source:  BioPlex
MAPK8IP2
Tbio
Family:  Enzyme
Novelty:  0.01788453
p_int:  0.999999151
p_ni:  8.49e-7
Score:  0.657
Data Source:  BioPlex,STRINGDB
FNBP4
Tdark
Novelty:  0.17447776
p_int:  0.999996759
p_ni:  0.000003241
Data Source:  BioPlex
SCN5A
Tclin
Family:  IC
Novelty:  0.00050944
p_int:  0.999987629
p_ni:  0.00000231
p_wrong:  0.000010061
Score:  0.918
Data Source:  BioPlex,STRINGDB
CTDP1
Tbio
Family:  Enzyme
Novelty:  0.01121863
p_int:  0.999986443
p_ni:  0.000001509
p_wrong:  0.000012048
Data Source:  BioPlex
AFF4
Tbio
Family:  TF
Novelty:  0.02113896
p_int:  0.99996644
p_ni:  0.00003356
Data Source:  BioPlex
DCAF16
Tdark
Novelty:  0.35666992
p_int:  0.999913226
p_ni:  0.000086362
p_wrong:  4.12e-7
Data Source:  BioPlex
WDR75
Tbio
Novelty:  0.09443914
p_int:  0.999910437
p_ni:  0.000089563
Data Source:  BioPlex
GPBP1L1
Tdark
Novelty:  0.69320833
p_int:  0.999882453
p_ni:  0.000110088
p_wrong:  0.000007459
Data Source:  BioPlex
CHD9
Tbio
Family:  Epigenetic
Novelty:  0.06234268
p_int:  0.99909962
p_ni:  0.000900351
p_wrong:  2.9e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 0 - rapid depolarisation
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 0 - rapid depolarisation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
17.8
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
fibroblast growth factor 12
705813
Mouse
MGI:109183
14167
Rat
RGD:620163
170630
Dog
fibroblast growth factor 12
VGNC:40841
478676
Horse
fibroblast growth factor 12
VGNC:18011
100059907
Species
Name
OMA
EggNOG
Inparanoid
Macaque
fibroblast growth factor 12
Mouse
Rat
Dog
fibroblast growth factor 12
Horse
fibroblast growth factor 12
Publication Statistics
PubMed Score 55.45
PubMed score by year
PubTator Score 27.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title