Tchem FGF1 Fibroblast growth factor 1

Protein Summary

Description

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107). The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]

Uniprot Accession IDs

• P05230
• B2R5T0
• D3DQF2
• P07502
• Q16588
• FGF-1

Gene Name

• FGF1

Ensembl ID

• ENST00000337706
• ENSP00000338548
• ENSG00000113578
• ENST00000359370
• ENSP00000352329
• ENST00000360966
• ENSP00000354231
• ENST00000378046
• ENSP00000367285
• ENST00000419524
• ENSP00000396195
• ENST00000441680
• ENSP00000404742
• ENST00000610990
• ENSP00000481868
• ENST00000612258
• ENSP00000479024
• ENST00000619447
• ENSP00000480980
• ENST00000621536
• ENSP00000480791

Symbol

• FGFA
• AFGF
• ECGF
• FGFA
• ECGFA
• ECGFB
• FGF-1
• HBGF1
• HBGF-1
• GLIO703
• ECGF-beta
• FGF-alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.97
disease perturbation	0.95
PubMedID	0.93
biological term	0.89
gene perturbation	0.82

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Fibroblast Growth Factor 1

DTO Classes

Protein / Signaling / Growth Factor / Fibroblast Growth Factor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1922.78   (req: < 5)

Gene RIFs: 148   (req: <= 3)

Antibodies: 684   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1922.78   (req: >= 5)

Gene RIFs: 148   (req: > 3)

Antibodies: 684   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 43

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0