You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FGD6
FYVE, RhoGEF and PH domain-containing protein 6

Protein Summary
Description
May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343958
  • ENSP00000344446
  • ENSG00000180263
  • ENST00000546711
  • ENSP00000450342

Symbol
  • KIAA1362
  • ZFYVE24
  • ZFYVE24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
kinase perturbation
0.88
protein domain
0.85
histone modification site profile
0.8
cell type or tissue
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.18   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.18   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
DBNL
Tbio
Novelty:  0.03390948
p_int:  0.999997457
p_ni:  0.000002535
p_wrong:  8e-9
Score:  0.507
Data Source:  BioPlex,STRINGDB
CCDC102B
Tbio
Novelty:  0.28075569
p_int:  0.99951383
p_ni:  0.00001602
p_wrong:  0.00047015
Score:  0.189
Data Source:  BioPlex,STRINGDB
APOD
Tbio
Novelty:  0.0031899
p_int:  0.804283158
p_ni:  0.195531036
p_wrong:  0.000185806
Data Source:  BioPlex
USP16
Tbio
Family:  Enzyme
Novelty:  0.13211126
Score:  0.72
Data Source:  STRINGDB
SLC7A5
Tchem
Family:  Transporter
Novelty:  0.00365806
Score:  0.711
Data Source:  STRINGDB
TRIB3
Tbio
Family:  Kinase
Novelty:  0.00827893
Score:  0.655
Data Source:  STRINGDB
MOCOS
Tbio
Family:  Enzyme
Novelty:  0.05022905
Score:  0.65
Data Source:  STRINGDB
ASNS
Tchem
Family:  Enzyme
Novelty:  0.00337445
Score:  0.648
Data Source:  STRINGDB
CFAP54
Tdark
Novelty:  0.91673101
Score:  0.641
Data Source:  STRINGDB
SLC7A11
Tchem
Family:  Transporter
Novelty:  0.00238054
Score:  0.641
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
4
3
1.1
95.8
2
2
2
89.5
FEV/FEC ratio
1
1
1
77
pulse pressure measurement
1
1
1
67.1
1
1
0
1.1
59.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
95.8
2
89.5
FEV/FEC ratio
1
77
pulse pressure measurement
1
67.1
0
1.1
59.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FYVE, RhoGEF and PH domain containing 6
VGNC:13065
452135
Macaque
FYVE, RhoGEF and PH domain containing 6
712132
Mouse
MGI:1261419
13998
Rat
RGD:1565609
500824
Dog
FYVE, RhoGEF and PH domain containing 6
VGNC:40838
482608
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FYVE, RhoGEF and PH domain containing 6
Macaque
FYVE, RhoGEF and PH domain containing 6
Mouse
Rat
Dog
FYVE, RhoGEF and PH domain containing 6
Publication Statistics
PubMed Score 25.18
PubMed score by year
PubTator Score 4.62
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title