Tbio FGD3 FYVE, RhoGEF and PH domain-containing protein 3

Protein Summary

Description

Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity).

Uniprot Accession IDs

• Q5JSP0
• F8W7P2
• Q4VX84
• Q7Z7D9
• Q8N5G1

Gene Name

• FGD3

Ensembl ID

• ENST00000337352
• ENSP00000336914
• ENSG00000127084
• ENST00000375482
• ENSP00000364631
• ENST00000416701
• ENSP00000413833
• ENST00000467786
• ENSP00000432310
• ENST00000468206
• ENSP00000496819

Symbol

• ZFYVE5
• ZFYVE5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
kinase perturbation	0.76
interacting protein	0.71
histone modification site profile	0.63
trait	0.61

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Fyve, Rhogef And Ph Domain-containing Protein 3

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Fyve, Rhogef And Ph Domain-containing Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.69   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 138   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.69   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0