Tbio FGB Fibrinogen beta chain

Protein Summary

Description

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Uniprot Accession IDs

• P02675
• A0JLR9
• B2R7G3
• Q32Q65
• Q3KPF2

Gene Name

• FGB

Ensembl ID

• ENST00000302068
• ENSP00000306099
• ENSG00000171564

Symbol

• HEL-S-78p

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.97
gene perturbation	0.97
cell type or tissue	0.76
protein domain	0.73
kinase perturbation	0.71

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Fibrinogen Beta Chain

DTO Classes

Protein / Signaling / Fibrinogen Beta Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.31   (req: < 5)

Gene RIFs: 186   (req: <= 3)

Antibodies: 539   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.31   (req: >= 5)

Gene RIFs: 186   (req: > 3)

Antibodies: 539   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (325)

Explore Interacting Targets

1 – 10 of 325

• See Interactions on String-DB

HIST1H2BJ

Tbio

Novelty:  0.14308844

p_int:  0.999998979

p_ni:  0.000001021

Data Source:  BioPlex

DDX19B

Tbio

Family:  Enzyme

Novelty:  0.0504568

p_int:  0.999996292

p_ni:  0.000003707

p_wrong:  1e-9

Data Source:  BioPlex

DDX1

Tchem

Family:  Enzyme

Novelty:  0.01691884

p_int:  0.999993491

p_ni:  0.000006505

p_wrong:  4e-9

Data Source:  BioPlex

SBDS

Tbio

Novelty:  0.00818779

p_int:  0.99999258

p_ni:  0.000007416

p_wrong:  4e-9

Data Source:  BioPlex

MAPK6

Tbio

Family:  Kinase

Novelty:  0.01012514

p_int:  0.999970544

p_ni:  0.000029456

Data Source:  BioPlex

SNX27

Tbio

Novelty:  0.02419724

p_int:  0.999794936

p_ni:  0.000205061

p_wrong:  3e-9

Data Source:  BioPlex

SPR

Tchem

Family:  Enzyme

Novelty:  0.02144934

p_int:  0.999789107

p_ni:  0.000210891

p_wrong:  2e-9

Score:  0.189

Data Source:  BioPlex,STRINGDB

SLC6A1

Tclin

Family:  Transporter

Novelty:  0.00165116

p_int:  0.999654382

p_ni:  0.00034561

p_wrong:  8e-9

Data Source:  BioPlex

ALDH2

Tclin

Family:  Enzyme

Novelty:  0.00077122

p_int:  0.999647588

p_ni:  0.000352412

Score:  0.302

Data Source:  BioPlex,STRINGDB

ADK

Tchem

Family:  Kinase

Novelty:  0.00196435

p_int:  0.999415969

p_ni:  0.0000038

p_wrong:  0.00058023

Score:  0.2

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (3)

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Upstream (3)

1 – 3 of 3

F2

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  2

1: Complement and coagulation cascades

2: Platelet activation

ITGB3

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  1

1: Platelet activation

ITGA2B

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  1

1: Platelet activation

Pathways (68)

Reactome (34)

KEGG (2)

PathwayCommons (6)

WikiPathways (26)

Common Pathway of Fibrin Clot Formation (R-HSA-140875)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Common Pathway of Fibrin Clot Formation	22 targets	R-HSA-140875
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases of signal transduction	387 targets	R-HSA-5663202
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244

Name	Explore in Pharos	Explore in Source
Common Pathway of Fibrin Clot Formation	22 targets	R-HSA-140875
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Disease	1105 targets	R-HSA-1643685
Diseases of signal transduction	387 targets	R-HSA-5663202
Extracellular matrix organization	297 targets	R-HSA-1474244

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (45)

Functions (4)

Components (15)

Processes (26)

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1 – 4 of 4

GO Term	Evidence	Assigned by
structural molecule activity	Inferred from Direct Assay (IDA)	BHF-UCL
chaperone binding	Inferred from Physical Interaction (IPI)	BHF-UCL
extracellular matrix structural constituent	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
signaling receptor binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (9)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
fibrinogen measurement	EFO_0004623	8	14	14	12.9	99.8
venous thromboembolism	EFO_0004286	7	5	2	1.2	98.2
low density lipoprotein cholesterol measurement	EFO_0004611	3	3	3		89.2
prothrombin time measurement	EFO_0008390	1	1	1		72.9
total cholesterol measurement	EFO_0004574	3	2	3		70.5

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5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
fibrinogen measurement	EFO_0004623	14	12.9	99.8
venous thromboembolism	EFO_0004286	2	1.2	98.2
low density lipoprotein cholesterol measurement	EFO_0004611	3		89.2
prothrombin time measurement	EFO_0008390	1		72.9
total cholesterol measurement	EFO_0004574	3		70.5

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Adaptive immunity
Blood coagulation
Coiled coil
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Hemostasis

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein B measurement
bilirubin measurement
fibrinogen measurement
glycine measurement
low density lipoprotein cholesterol measurement
partial thromboplastin time
prothrombin time measurement
total cholesterol measurement
venous thromboembolism

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
endocrine/exocrine gland phenotype
homeostasis/metabolism phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	fibrinogen beta chain	VGNC:606	461558
Macaque	fibrinogen beta chain		698487
Mouse	fibrinogen beta chain	MGI:99501	110135
Rat	fibrinogen beta chain	RGD:2604	24366
Dog	fibrinogen beta chain	VGNC:54207	475472

Species	Name	OMA	EggNOG	Inparanoid
Chimp	fibrinogen beta chain
Macaque	fibrinogen beta chain
Mouse	fibrinogen beta chain
Rat	fibrinogen beta chain
Dog	fibrinogen beta chain

Publication Statistics

PubMed Score 226.31

PubMed score by year

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PubTator Score 16491.75

PubTator score by year

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Related Publications

Text Mined References (394)

GeneRif Annotations (186)

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PMID	Year	Title