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Tchem
FFAR3
Free fatty acid receptor 3

Protein Summary
Description
G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation (PubMed:12711604). Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327809
  • ENSP00000328230
  • ENSG00000185897
  • ENST00000594310
  • ENSP00000469522

Symbol
  • GPR41
  • FFA3R
  • GPR41
  • GPR42
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.71
phenotype
0.62
tissue
0.62
cell type or tissue
0.51
cell line
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.18   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.18   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (181)
FFAR4
Tchem
Family:  GPCR
Novelty:  0.00439747
Score:  0.982
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.966
Data Source:  STRINGDB
GPRC6A
Tchem
Family:  GPCR
Novelty:  0.01625616
Score:  0.956
Data Source:  STRINGDB
CCK
Tbio
Novelty:  0.00012268
Score:  0.946
Data Source:  STRINGDB
CASR
Tclin
Family:  GPCR
Novelty:  0.00061316
Score:  0.933
Data Source:  STRINGDB
CCKAR
Tclin
Family:  GPCR
Novelty:  0.00152339
Score:  0.922
Data Source:  STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.921
Data Source:  STRINGDB
FFAR1
Tchem
Family:  GPCR
Novelty:  0.00271782
Score:  0.921
Data Source:  STRINGDB
GAST
Tbio
Novelty:  0.00011795
Score:  0.916
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.915
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Free fatty acid receptors
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Free fatty acid receptors
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
7
9
92.2
hemoglobin measurement
4
4
4
71.6
mean corpuscular hemoglobin concentration
1
1
1
63.8
monocyte percentage of leukocytes
1
1
1
48.8
red blood cell density measurement
1
1
1
43.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
9
92.2
hemoglobin measurement
4
71.6
mean corpuscular hemoglobin concentration
1
63.8
monocyte percentage of leukocytes
1
48.8
red blood cell density measurement
1
43.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
free fatty acid receptor 3
455946
Mouse
MGI:2685324
233080
Rat
RGD:1311035
365228
Horse
free fatty acid receptor 3
102150446
Cow
free fatty acid receptor 3
527517
Species
Name
OMA
EggNOG
Inparanoid
Chimp
free fatty acid receptor 3
Mouse
Rat
Horse
free fatty acid receptor 3
Cow
free fatty acid receptor 3
Publication Statistics
PubMed Score 199.18
PubMed score by year
PubTator Score 38.65
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title