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Tchem
FFAR1
Free fatty acid receptor 1

Protein Summary
Description
G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246553
  • ENSP00000246553
  • ENSG00000126266

Symbol
  • GPR40
  • FFA1R
  • GPR40
  • GPCR40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.77
biological process
0.65
tissue
0.64
ligand (chemical)
0.61
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 477.48   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 306   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 477.48   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 620
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1