FFAR1
Free fatty acid receptor 1
Protein Summary
G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provi ...more
- ENST00000246553
- ENSP00000246553
- ENSG00000126266
- GPR40
- FFA1R
- GPR40
- GPCR40
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.77 | ||
biological process | 0.65 | ||
tissue | 0.64 | ||
ligand (chemical) | 0.61 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 447.25 (req: < 5)
Gene RIFs: 52 (req: <= 3)
Antibodies: 306 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 447.25 (req: >= 5)
Gene RIFs: 52 (req: > 3)
Antibodies: 306 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 555
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (555)
Protein-Protein Interactions (193)
Nearest Tclin Targets
Pathways (20)
Reactome (17)
KEGG (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | ||||
Reactome | Free fatty acid receptors | ||||
Reactome | Free fatty acids regulate insulin secretion | ||||
Reactome | G alpha (q) signalling events | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | ||||
Free fatty acid receptors | ||||
Free fatty acids regulate insulin secretion | ||||
G alpha (q) signalling events | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (4)
Components (2)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 4 | 5 | 7 | 92.3 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 73.5 | |||||
monocyte percentage of leukocytes | 1 | 1 | 1 | 59 | |||||
red blood cell density measurement | 1 | 1 | 1 | 53.7 | |||||
lymphocyte count | 1 | 1 | 1 | 47.7 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 7 | 92.3 | |||||
mean corpuscular hemoglobin concentration | 1 | 73.5 | |||||
monocyte percentage of leukocytes | 1 | 59 | |||||
red blood cell density measurement | 1 | 53.7 | |||||
lymphocyte count | 1 | 47.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | free fatty acid receptor 1 | VGNC:11075 | 468836 | |||||
Macaque | free fatty acid receptor 1 | 708620 | ||||||
Mouse | MGI:2684079 | 233081 | ||||||
Rat | RGD:628613 | 266607 | ||||||
Dog | free fatty acid receptor 1 | VGNC:40830 | 612661 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | free fatty acid receptor 1 | |||||
Macaque | free fatty acid receptor 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | free fatty acid receptor 1 | |||||
Publication Statistics
PubMed Score 447.25
PubMed score by year
PubTator Score 206.56
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (65)
GeneRif Annotations (52)
Items per page:
0 of 0
PMID | Year | Title |
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