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Tbio
FEZF1
Fez family zinc finger protein 1

Protein Summary
Description
Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors (By similarity). This gene encodes a transcriptional repressor that belongs to the zinc finger double domain protein family. The encoded protein is thought to play a role in the embryonic migration of gonadotropin-releasing hormone neurons into the brain. Mutations in this gene are associated with hypogonadotropic hypogonadism-22 with anosmia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000427185
  • ENSP00000392727
  • ENSG00000128610
  • ENST00000442488
  • ENSP00000411145

Symbol
  • FEZ
  • ZNF312B
  • FEZ
  • HH22
  • ZNF312B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.8
molecular function
0.67
cell type or tissue
0.56
tissue
0.51
gene perturbation
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.5   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.5   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
P3H2
Tbio
Family:  Enzyme
Novelty:  0.04237396
p_int:  0.999913454
p_ni:  0.000086004
p_wrong:  5.42e-7
Data Source:  BioPlex
DGKZ
Tchem
Family:  Enzyme
Novelty:  0.01312044
p_int:  0.999751874
p_ni:  0.00024812
p_wrong:  5e-9
Data Source:  BioPlex
SORL1
Tbio
Novelty:  0.00380895
p_int:  0.999224241
p_ni:  0.000775759
Data Source:  BioPlex
CENPB
Tbio
Novelty:  0.0036225
p_int:  0.999083456
p_ni:  0.00091653
p_wrong:  1.4e-8
Score:  0.166
Data Source:  BioPlex,STRINGDB
CUL9
Tbio
Novelty:  0.1104365
p_int:  0.999029053
p_ni:  0.000970947
Data Source:  BioPlex
LRP1B
Tbio
Novelty:  0.01443405
p_int:  0.998601827
p_ni:  0.001398173
Data Source:  BioPlex
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
p_int:  0.995898121
p_ni:  0.004101879
Data Source:  BioPlex
LRP4
Tbio
Novelty:  0.01336125
p_int:  0.987656411
p_ni:  0.012343588
Data Source:  BioPlex
MTMR4
Tbio
Family:  Enzyme
Novelty:  0.09166984
p_int:  0.987560673
p_ni:  0.012359104
p_wrong:  0.000080224
Data Source:  BioPlex
IFT81
Tbio
Novelty:  0.01610195
p_int:  0.972317724
p_ni:  0.027682274
p_wrong:  2e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
1
1
61
body mass index
1
1
1
57.3
facial morphology measurement
1
1
2
56.6
diet measurement
2
1
2
51.7
risk-taking behaviour
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
61
body mass index
1
57.3
facial morphology measurement
2
56.6
diet measurement
2
51.7
risk-taking behaviour
1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FEZ family zinc finger 1
VGNC:4356
463682
Macaque
FEZ family zinc finger 1
100429986
Mouse
MGI:1920441
73191
Rat
RGD:1560480
500048
Horse
FEZ family zinc finger 1
VGNC:18000
100071453
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FEZ family zinc finger 1
Macaque
FEZ family zinc finger 1
Mouse
Rat
Horse
FEZ family zinc finger 1
Publication Statistics
PubMed Score 50.50
PubMed score by year
PubTator Score 140.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title