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Tbio
FEZ1
Fasciculation and elongation protein zeta-1

Protein Summary
Description
May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278919
  • ENSP00000278919
  • ENSG00000149557
  • ENST00000366139
  • ENSP00000393425
  • ENST00000524435
  • ENSP00000431521
  • ENST00000648911
  • ENSP00000497070

Symbol
  • UNC-76
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
PubMedID
0.94
kinase perturbation
0.91
small molecule perturbation
0.74
tissue sample
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.45   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.45   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
SCOC
Tbio
Novelty:  0.05277646
p_int:  0.999999939
p_ni:  6.1e-8
Score:  0.958
Data Source:  BioPlex,STRINGDB
ANK3
Tbio
Novelty:  0.00429246
p_int:  0.999993726
p_ni:  0.000006274
Score:  0.203
Data Source:  BioPlex,STRINGDB
DGKD
Tbio
Family:  Enzyme
Novelty:  0.03749316
p_int:  0.999992389
p_ni:  7.6e-8
p_wrong:  0.000007534
Score:  0.309
Data Source:  BioPlex,STRINGDB
ZYG11A
Tbio
Novelty:  0.13413639
p_int:  0.999991041
p_ni:  0.000008959
Score:  0.347
Data Source:  BioPlex,STRINGDB
NELFA
Tbio
Novelty:  0.09727823
p_int:  0.99996803
p_ni:  0.00003197
Score:  0.185
Data Source:  BioPlex,STRINGDB
TUBA3C
Tchem
Novelty:  0.0187396
p_int:  0.999952625
p_ni:  0.000047375
Data Source:  BioPlex
CEP192
Tbio
Novelty:  0.05738998
p_int:  0.999633319
p_ni:  0.000366645
p_wrong:  3.6e-8
Score:  0.546
Data Source:  BioPlex,STRINGDB
KLHDC2
Tbio
Novelty:  0.01485159
p_int:  0.997654832
p_ni:  0.002345168
Data Source:  BioPlex
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
p_int:  0.97554102
p_ni:  0.02445898
Data Source:  BioPlex
HTT
Tchem
Novelty:  0.00034051
p_int:  0.974741746
p_ni:  0.025258253
p_wrong:  1e-9
Score:  0.261
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
1
1
74.3
heel bone mineral density
2
2
2
66.1
1
1
0
1.9
62.1
1
1
0
1.9
62.1
1
1
0
1.9
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
74.3
heel bone mineral density
2
66.1
0
1.9
62.1
0
1.9
62.1
0
1.9
62.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fasciculation and elongation protein zeta 1
VGNC:1059
451647
Macaque
fasciculation and elongation protein zeta 1
713106
Mouse
MGI:2670976
235180
Rat
RGD:619708
81730
Dog
fasciculation and elongation protein zeta 1
VGNC:40827
612764
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fasciculation and elongation protein zeta 1
Macaque
fasciculation and elongation protein zeta 1
Mouse
Rat
Dog
fasciculation and elongation protein zeta 1
Publication Statistics
PubMed Score 45.45
PubMed score by year
PubTator Score 42.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title