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Tbio
FERMT1
Fermitin family homolog 1

Protein Summary
Description
Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217289
  • ENSP00000217289
  • ENSG00000101311

Symbol
  • C20orf42
  • KIND1
  • URP1
  • URP1
  • KIND1
  • DTGCU2
  • UNC112A
  • C20orf42
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
protein domain
0.85
cellular component
0.73
virus perturbation
0.72
cell type or tissue
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.92   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.92   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
FERMT2
Tbio
Novelty:  0.01020276
p_int:  0.999999833
p_ni:  1.64e-7
p_wrong:  2e-9
Score:  0.834
Data Source:  BioPlex,STRINGDB
FERMT3
Tbio
Novelty:  0.01172918
p_int:  0.999999261
p_ni:  7.09e-7
p_wrong:  2.9e-8
Score:  0.841
Data Source:  BioPlex,STRINGDB
MAGI3
Tbio
Family:  Enzyme
Novelty:  0.03968945
p_int:  0.999613379
p_ni:  0.000386621
Score:  0.345
Data Source:  BioPlex,STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
p_int:  0.910723488
p_ni:  0.001171133
p_wrong:  0.088105378
Score:  0.187
Data Source:  BioPlex,STRINGDB
TARSL2
Tbio
Family:  Enzyme
Novelty:  0.02406282
p_int:  0.845645013
p_ni:  0.154354986
Score:  0.188
Data Source:  BioPlex,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
ILK
Tchem
Family:  Kinase
Novelty:  0.00147344
Score:  0.898
Data Source:  STRINGDB
TTC37
Tbio
Novelty:  0.02816322
Score:  0.855
Data Source:  STRINGDB
SKIV2L
Tbio
Family:  Enzyme
Novelty:  0.01108539
Score:  0.843
Data Source:  STRINGDB
FBLIM1
Tbio
Novelty:  0.0332985
Score:  0.814
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
fermitin family member 1
718297
Mouse
MGI:2443583
241639
Rat
RGD:1306816
296179
Dog
fermitin family member 1
VGNC:40822
485775
Horse
fermitin family member 1
VGNC:17994
100051761
Species
Name
OMA
EggNOG
Inparanoid
Macaque
fermitin family member 1
Mouse
Rat
Dog
fermitin family member 1
Horse
fermitin family member 1
Publication Statistics
PubMed Score 126.92
PubMed score by year
PubTator Score 99.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title