Tbio FERD3L Fer3-like protein

Protein Summary

Description

Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity).

Uniprot Accession IDs

• Q96RJ6
• Q495K0

Gene Name

• FERD3L

Ensembl ID

• ENST00000275461
• ENSP00000275461
• ENSG00000146618

Symbol

• BHLHA31
• NATO3
• NTWIST
• PTFB
• NATO3
• NTWIST
• N-TWIST
• bHLHa31

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.8
biological process	0.6
cell line	0.54
tissue	0.54
disease	0.42

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.41   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 82   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.41   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0