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Tbio
FERD3L
Fer3-like protein

Protein Summary
Description
Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275461
  • ENSP00000275461
  • ENSG00000146618

Symbol
  • BHLHA31
  • NATO3
  • NTWIST
  • PTFB
  • NATO3
  • NTWIST
  • N-TWIST
  • bHLHa31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
biological process
0.6
cell line
0.54
tissue
0.54
disease
0.42


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.86   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.86   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
TCF3
Tbio
Family:  TF
Novelty:  0.00112675
p_int:  0.999999987
p_ni:  1.3e-8
Score:  0.813
Data Source:  BioPlex,STRINGDB
TCF12
Tbio
Family:  TF
Novelty:  0.00381424
p_int:  0.999999966
p_ni:  3.4e-8
Score:  0.855
Data Source:  BioPlex,STRINGDB
TCF4
Tbio
Family:  TF
Novelty:  0.0019718
p_int:  0.999999927
p_ni:  7.3e-8
Score:  0.86
Data Source:  BioPlex,STRINGDB
USP19
Tbio
Family:  Enzyme
Novelty:  0.04078253
p_int:  0.999992248
p_ni:  0.000007752
Score:  0.187
Data Source:  BioPlex,STRINGDB
HEXIM2
Tbio
Novelty:  0.14814693
p_int:  0.998322067
p_ni:  0.001151387
p_wrong:  0.000526546
Score:  0.747
Data Source:  BioPlex,STRINGDB
NES
Tbio
Novelty:  0.00035379
p_int:  0.99466977
p_ni:  0.0053302
p_wrong:  3e-8
Score:  0.574
Data Source:  BioPlex,STRINGDB
DMWD
Tbio
Novelty:  0.04096001
p_int:  0.977078793
p_ni:  0.022921187
p_wrong:  2.1e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
CORO2A
Tbio
Novelty:  0.03292199
p_int:  0.906730442
p_ni:  0.06902017
p_wrong:  0.024249387
Score:  0.228
Data Source:  BioPlex,STRINGDB
TWIST2
Tbio
Family:  TF
Novelty:  0.00748285
Score:  0.803
Data Source:  STRINGDB
SNX13
Tbio
Novelty:  0.12227762
Score:  0.794
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
3
3
90.8
1
2
2
60.1
body height
1
1
1
17.8
heel bone mineral density
1
1
1
3.9
BMI-adjusted waist circumference
1
1
1
3.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
3
90.8
2
60.1
body height
1
17.8
heel bone mineral density
1
3.9
BMI-adjusted waist circumference
1
3.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fer3 like bHLH transcription factor
VGNC:14073
472301
Macaque
Fer3 like bHLH transcription factor
708009
Mouse
MGI:2150010
114712
Rat
RGD:1311812
366598
Dog
Fer3 like bHLH transcription factor
VGNC:40821
482340
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fer3 like bHLH transcription factor
Macaque
Fer3 like bHLH transcription factor
Mouse
Rat
Dog
Fer3 like bHLH transcription factor
Publication Statistics
PubMed Score 15.86
PubMed score by year
PubTator Score 4.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title