Tbio FERD3L Fer3-like protein

Protein Summary

Description

Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity).

Uniprot Accession IDs

• Q96RJ6
• Q495K0

Gene Name

• FERD3L

Ensembl ID

• ENST00000275461
• ENSP00000275461
• ENSG00000146618

Symbol

• BHLHA31
• NATO3
• NTWIST
• PTFB
• NATO3
• NTWIST
• N-TWIST
• bHLHa31

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.8
biological process	0.6
cell line	0.54
tissue	0.54
disease	0.42

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.86   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 82   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.86   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (40)

Explore Interacting Targets

1 – 10 of 40

• See Interactions on String-DB

TCF3

Tbio

Family:  TF

Novelty:  0.00112675

p_int:  0.999999987

p_ni:  1.3e-8

Score:  0.813

Data Source:  BioPlex,STRINGDB

TCF12

Tbio

Family:  TF

Novelty:  0.00381424

p_int:  0.999999966

p_ni:  3.4e-8

Score:  0.855

Data Source:  BioPlex,STRINGDB

TCF4

Tbio

Family:  TF

Novelty:  0.0019718

p_int:  0.999999927

p_ni:  7.3e-8

Score:  0.86

Data Source:  BioPlex,STRINGDB

USP19

Tbio

Family:  Enzyme

Novelty:  0.04078253

p_int:  0.999992248

p_ni:  0.000007752

Score:  0.187

Data Source:  BioPlex,STRINGDB

HEXIM2

Tbio

Novelty:  0.14814693

p_int:  0.998322067

p_ni:  0.001151387

p_wrong:  0.000526546

Score:  0.747

Data Source:  BioPlex,STRINGDB

NES

Tbio

Novelty:  0.00035379

p_int:  0.99466977

p_ni:  0.0053302

p_wrong:  3e-8

Score:  0.574

Data Source:  BioPlex,STRINGDB

DMWD

Tbio

Novelty:  0.04096001

p_int:  0.977078793

p_ni:  0.022921187

p_wrong:  2.1e-8

Score:  0.169

Data Source:  BioPlex,STRINGDB

CORO2A

Tbio

Novelty:  0.03292199

p_int:  0.906730442

p_ni:  0.06902017

p_wrong:  0.024249387

Score:  0.228

Data Source:  BioPlex,STRINGDB

TWIST2

Tbio

Family:  TF

Novelty:  0.00748285

Score:  0.803

Data Source:  STRINGDB

SNX13

Tbio

Novelty:  0.12227762

Score:  0.794

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (4)

Components (1)

Processes (4)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA-binding transcription repressor activity, RNA polymerase II-specific	Inferred from Electronic Annotation (IEA)	Ensembl
protein dimerization activity	Inferred from Electronic Annotation (IEA)	InterPro
RNA polymerase II regulatory region sequence-specific DNA binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (7)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
balding measurement	EFO_0007825	1	3	3		90.8
Alopecia	Orphanet_79364	1	2	2		60.1
body height	EFO_0004339	1	1	1		17.8
heel bone mineral density	EFO_0009270	1	1	1		3.9
BMI-adjusted waist circumference	EFO_0007789	1	1	1		3.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
balding measurement	EFO_0007825	3		90.8
Alopecia	Orphanet_79364	2		60.1
body height	EFO_0004339	1		17.8
heel bone mineral density	EFO_0009270	1		3.9
BMI-adjusted waist circumference	EFO_0007789	1		3.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
DNA-binding
Nucleus
Polymorphism
Reference proteome
Repressor
Transcription
Transcription regulation

GWAS Trait Find Similar Targets

No Header	No Header
Alopecia
balding measurement
BMI-adjusted hip circumference
BMI-adjusted waist circumference
body height
heel bone mineral density
serum albumin measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
embryo phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	Fer3 like bHLH transcription factor	VGNC:14073	472301
Macaque	Fer3 like bHLH transcription factor		708009
Mouse	Fer3 like bHLH transcription factor	MGI:2150010	114712
Rat	Fer3-like bHLH transcription factor	RGD:1311812	366598
Dog	Fer3 like bHLH transcription factor	VGNC:40821	482340

Species	Name	OMA	EggNOG	Inparanoid
Chimp	Fer3 like bHLH transcription factor
Macaque	Fer3 like bHLH transcription factor
Mouse	Fer3 like bHLH transcription factor
Rat	Fer3-like bHLH transcription factor
Dog	Fer3 like bHLH transcription factor

Publication Statistics

PubMed Score 15.86

PubMed score by year

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PubTator Score 4.92

PubTator score by year

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Related Publications

Text Mined References (9)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title