Protein Summary
Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity).
- ENST00000275461
- ENSP00000275461
- ENSG00000146618
- BHLHA31
- NATO3
- NTWIST
- PTFB
- NATO3
- NTWIST
- N-TWIST
- bHLHa31
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell type or tissue | 0.8 | ||
biological process | 0.6 | ||
cell line | 0.54 | ||
tissue | 0.54 | ||
disease | 0.42 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15.86 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 82 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15.86 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 82 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (40)
TCF3
Family: TF
Novelty: 0.00112675
p_int: 0.999999987
p_ni: 1.3e-8
Score: 0.813
Data Source: BioPlex,STRINGDB
TCF12
Family: TF
Novelty: 0.00381424
p_int: 0.999999966
p_ni: 3.4e-8
Score: 0.855
Data Source: BioPlex,STRINGDB
TCF4
Family: TF
Novelty: 0.0019718
p_int: 0.999999927
p_ni: 7.3e-8
Score: 0.86
Data Source: BioPlex,STRINGDB
USP19
Family: Enzyme
Novelty: 0.04078253
p_int: 0.999992248
p_ni: 0.000007752
Score: 0.187
Data Source: BioPlex,STRINGDB
HEXIM2
Novelty: 0.14814693
p_int: 0.998322067
p_ni: 0.001151387
p_wrong: 0.000526546
Score: 0.747
Data Source: BioPlex,STRINGDB
NES
Novelty: 0.00035379
p_int: 0.99466977
p_ni: 0.0053302
p_wrong: 3e-8
Score: 0.574
Data Source: BioPlex,STRINGDB
DMWD
Novelty: 0.04096001
p_int: 0.977078793
p_ni: 0.022921187
p_wrong: 2.1e-8
Score: 0.169
Data Source: BioPlex,STRINGDB
CORO2A
Novelty: 0.03292199
p_int: 0.906730442
p_ni: 0.06902017
p_wrong: 0.024249387
Score: 0.228
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (4)
Components (1)
Processes (4)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
balding measurement | 1 | 3 | 3 | 90.8 | |||||
1 | 2 | 2 | 60.1 | ||||||
body height | 1 | 1 | 1 | 17.8 | |||||
heel bone mineral density | 1 | 1 | 1 | 3.9 | |||||
BMI-adjusted waist circumference | 1 | 1 | 1 | 3.6 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
balding measurement | 3 | 90.8 | |||||
2 | 60.1 | ||||||
body height | 1 | 17.8 | |||||
heel bone mineral density | 1 | 3.9 | |||||
BMI-adjusted waist circumference | 1 | 3.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | Fer3 like bHLH transcription factor | VGNC:14073 | 472301 | |||||
Macaque | Fer3 like bHLH transcription factor | 708009 | ||||||
Mouse | MGI:2150010 | 114712 | ||||||
Rat | RGD:1311812 | 366598 | ||||||
Dog | Fer3 like bHLH transcription factor | VGNC:40821 | 482340 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | Fer3 like bHLH transcription factor | |||||
Macaque | Fer3 like bHLH transcription factor | |||||
Mouse | ||||||
Rat | ||||||
Dog | Fer3 like bHLH transcription factor | |||||
Publication Statistics
PubMed Score 15.86
PubMed score by year
PubTator Score 4.92
PubTator score by year
Related Publications
Text Mined References (9)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
---|